Aminophylline – A-Z Drugs


What’s the drug Aminophylline used for?

Aminophylline is a drugs to deal with cough and problem respiratory because of extended lung illness (for instance bronchial asthma, emphysema, and power bronchitis).

Aminophylline belongs to a category of medication known as xanthine. This drug works within the airways by stress-free muscle tissue, opening airways to revive respiratory, and lowering the lung's response to international substances.

This drug doesn’t work instantly and shouldn’t be used for sudden onset of respiratory misery. Your physician ought to prescribe treatment or immediate suckers (reminiscent of albuterol) for sudden shortness of breath or bronchial asthma while you’re utilizing this medication.

You must at all times carry this immediate sucker in every single place. Seek the advice of a health care provider or pharmacist for additional particulars.

What are the foundations for utilizing Aminophylline?

Aminophylline could be taken earlier than or after meals. This medication is normally taken 2-Four instances or based on physician's instructions. If this medication makes you sick to your abdomen, you’ll be able to take it with meals.

Don’t crush or chew the prolonged tablets as a result of they will launch all medication at one time, which will increase the danger of unwanted side effects.

Additionally, don’t break up the pill if it doesn’t have a dividing line on the drug, or if the physician or pharmacist doesn’t inform you to take action. You may swallow or divide a pill with out breaking or chewing it first.

The dosage for this drug is set based mostly on medical situations, response to remedy, age, physique weight, blood drug ranges, and different medication that you could be be taking.

Use this medication commonly to get most outcomes. That will help you bear in mind, drink it on the similar time daily. Inform your physician in case your situation doesn't enhance or it will get worse.

The way to retailer Aminophylline?

Retailer treatment at room temperature, away from publicity to gentle and moisture. Don’t retailer within the rest room and don’t freeze. Medicine with totally different manufacturers could have other ways of storing.

Examine the product field for directions on the right way to retailer it, or ask the pharmacist. Preserve treatment away from youngsters and pets.

Don’t flush medication in the bathroom or throw it into the drain if not instructed to. Get rid of this product correctly whether it is previous the due date otherwise you not want it.

Seek the advice of with a pharmacist or native waste disposal company for extra in-depth particulars on the right way to safely get rid of the product.


The knowledge offered just isn’t an alternative to medical recommendation. ALWAYS seek the advice of a health care provider or pharmacist earlier than beginning remedy.

What’s the dose of Aminophylline for adults?

Intravenous (IV): all doses based mostly on aminophylline — sufferers not receiving aminophyline or theophylline

  • Preliminary dose (Loading dose): 6 mg / kg in 100-200 mL IV fluid by infusion as soon as in 20-30 minutes.
  • Upkeep dose (after preliminary dose):
  • Wholesome adults who don’t smoke: 0.7 mg / kg / hour steady intravenous infusion.
  • Younger grownup people who smoke: 0.9 mg / kg / hour steady intravenous infusion.
  • Sufferers with cor pulmonale or congestive coronary heart failure: 0.25 mg / kg / hour steady intravenous infusion.

Oral: Sufferers who don’t obtain aminophylline or theophylline

  • Preliminary dose (Loading Dosage): 6.Three mg / kg orally.
  • Upkeep dose: (after preliminary dose):
  • Wholesome adults who don't smoke: 12.5 mg / kg / day in separate doses. Don’t exceed 1,125 mg / day.
  • Younger grownup people who smoke: 19 mg / kg / day in separate doses.
  • Sufferers with cor pulmonale or congestive coronary heart failure: 6.25 mg / kg / day in separate doses. Don’t exceed 500 mg / day.

What’s the dose of Aminophylline for kids?

Youngsters's dose for untimely apnea

Infants Four weeks and over: (IV or oral, all doses based mostly on aminophylline):
  • Preliminary dose (Loading dose): (Sufferers who don’t obtain aminophylline or theophylline): 5-6 mg / kg as soon as – if diluted in IV fluids and given intravenously as soon as for 20-30 minutes.
  • Upkeep dose: 3-Eight mg / kg / day aside each 6-12 hours

Youngsters's dosage for acute bronchial asthma

IV: (all doses based mostly on aminophylline and sufferers not receiving aminophylline or theophylline):
  • Preliminary dose (Loading dose) for therapeutic bronchial asthma: 6 mg / kg diluted in IV fluids by infusion as soon as for 20-30 minutes.
  • Upkeep dose (after administration dose):
  • 6 weeks-6 months: 0.5 mg / kg / hour steady intravenous infusion.
  • 6 months-1 yr: 0.6-0.7 mg / kg / hour steady intravenous infusion.
  • 1-9 years: 1-1.2 mg / kg / hour steady intravenous infusion.
  • 9-12 years: 0.9 mg / kg / hour steady intravenous infusion.
  • > 12 years: 0.7 mg / kg / hour steady intravenous infusion.
Oral: (Sufferers who don’t obtain aminophylline or theophylline):
  • Preliminary dose (Loading dose): 6.Three mg / kg orally.
  • Upkeep dose (after administration dose):
  • 42 – 182 days: 12-13.5 mg / kg / day in separate doses.
  • 6 – 12 months: 15-22.5 mg / kg / day in separate doses.
  • 1 – 9 years: 25-30 mg / kg / day in separate doses.
  • 9-12 years: 17-20 mg / kg / day in separate doses.
  • 12-16 years: 15-17 mg / kg in separate doses.
  • 16 years and over: 6.25-20 mg / kg in separate doses.

In what dosages and preparations is Aminophylline accessible?

This drug is offered in injection options and tablets: 105 mg / 5 ml.

Negative effects

What unwanted side effects may happen because of Aminophylline?

When you expertise the next critical unwanted side effects, cease utilizing aminophylline and search quick medical consideration:

  • Allergic response (problem respiratory, narrowing of the throat, swelling of the lips, tongue, or face or itching)
  • Convulsions
  • Elevated or irregular heartbeat or
  • Extreme nausea or vomiting.
  • Chest ache

Different milder unwanted side effects can also happen, though they not often happen on the proper dose. Proceed to take aminophylline and speak together with your physician for those who expertise:

  • Gentle nausea, decreased urge for food, or decreased physique weight
  • Restlessness, trembling, or insomnia
  • Headache, fainting, or dizziness.
  • The quantity of urine will increase

There are additionally unwanted side effects that don’t require medical help, as a result of they disappear over time as you adapt to this treatment, together with:

  • Gentle headache
  • Simple to get offended
  • Insomnia, couldn’t even sleep in any respect
  • At all times feeling much less rested

Not everybody experiences the unwanted side effects talked about. There could also be some unwanted side effects not talked about above. When you expertise considerations about sure unwanted side effects, seek the advice of your physician or pharmacist.

Prevention & Warnings

What should be recognized earlier than utilizing Aminophylline?

Earlier than utilizing this medication to treatment bronchial asthma, inform your physician and pharmacist:

  • In case you are allergic to aminophylline or different medication
  • Concerning the record of pharmaceuticals that you’re presently taking, particularly
    • allopurinol (Zyloprim)
    • azithromycin (Zithromax)
    • carbamazepine (Tegretol)
    • cimetidine (Tagamet)
    • ciprofloxacin (Cipro)
    • clarithromycin (Biaxin)
    • diuretic (water capsule ’)
    • erythromycin
    • lithium (Eskalith, Lithobid)
    • oral contraceptives
    • phenytoin (Dilantin)
    • prednisone (Deltasone)
    • propranolol (Inderal)
    • rifampin (Rifadin)
    • tetracycline (Sumycin)
    • different medicines for an infection or coronary heart illness.
  • Understanding prescription and non-prescription medication that you’re presently taking, particularly over-the-counter medication that comprise ephedrine, epinephrine, phenylephrine, phenylpropanolamine, or pseudoephedrine. Many over-the-counter medicines comprise these medication (reminiscent of slimming capsules and chilly and bronchial asthma medicines), so test the labels rigorously. Don’t take this medication with out speaking to a health care provider as a result of it will possibly improve the unwanted side effects of aminophylline.
  • In case you have or have had a seizure, coronary heart illness, thyroid gland too or utterly inactive, hypertension, or liver illness or you’ve got a historical past of alcohol abuse.
  • In case you are pregnant, planning to turn into pregnant, or breastfeeding. When you turn into pregnant whereas utilizing aminophylline, name your physician.
  • When you use tobacco merchandise. Smoking may have an effect on the mechanism of motion of aminophylline in your physique.

Is Aminophylline protected for pregnant or nursing ladies?

Aminophylline absorption in your physique may change if you’re pregnant. Nonetheless, in research carried out on animals, within the quantity of thrice the really helpful dosage for people, no indicators of defects had been proven.

Even so, there is no such thing as a satisfactory analysis on the dangers of utilizing this drug in pregnant or nursing ladies. At all times seek the advice of your physician to contemplate the potential advantages and dangers earlier than utilizing this medication.

This drug is included within the threat of being pregnant class C based mostly on a class created by the US Meals and Drug Administration (FDA).

Being pregnant threat classes based on the FDA:

  • A = No threat
  • B = No threat in a number of research
  • C = Perhaps dangerous
  • D = There’s optimistic proof of threat
  • X = Contraindications
  • N = Unknown

In the meantime, aminophylline can enter breast milk and be capable to have an effect on the child. Don’t take aminophylline if you’re breastfeeding with out speaking to your physician beforehand if you’re breastfeeding.


What medicines may work together with Aminophylline?

Drug interactions may change the way in which medication work or improve the danger of great unwanted side effects. This text doesn’t cowl all attainable drug interactions with aminophylline.

Preserve a listing of all of the medicinal merchandise you employ (together with prescription / non-prescription medication and natural merchandise) and notify the physician and pharmacist. Don’t begin, cease or change the dosage of the drug with out the physician's approval.

  • Alcohol
  • Cimetidine (Tagamet, Tagamet HB)
  • Fluoroquinolone antibiotics reminiscent of enoxacin (Penetrex), lomefloxacin (Maxaquin), ciprofloxacin (Cipro), norfloxacin (Noroxin), and ofloxacin (Floxin)
  • Clarithromycin (Biaxin) and erythromycin (Ery-Tab, E.E.S., E-Mycin, and many others.)
  • Disulfiram (Antabuse)
  • Estrogen (Ogen, Premarin and lots of different sorts)
  • Fluvoxamine (Luvox)
  • Methotrexate (Folex, Rheumatrex)
  • Mexiletine (Mexitil) and propafenone (Rythmol)
  • Propranolol (Inderal)
  • Tacrine (Cognex)
  • Ticlopidine (Ticlid) and
  • Verapamil (Verelan, Calan, Isoptin).

The next medication could cut back aminophylline ranges within the blood, which makes bronchial asthma tougher to manage:

  • Aminoglutethimide (Cytadren),
  • Carbamazepine (Tegretol),
  • Isoproterenol (Isuprel),
  • Moricizine (Ethmozine),
  • Phenobarbital (Luminal, Solfoton),
  • Phenytoin (Dilantin),
  • Rifampin (Rifadin), and
  • Sucralfate (Carafate).

Can meals or alcohol work together with Aminophylline?

Sure medicines can’t be used when consuming or when consuming sure meals as a result of drug interactions can happen.

Consuming alcohol or tobacco with sure medication may trigger interactions to happen. Discuss to an expert well being care supplier about utilizing medication with meals, alcohol or tobacco.

What well being situations can work together with Aminophylline?

Different medical problems could have an effect on using medication that can be utilized to deal with bronchitis. Make sure to inform your physician if in case you have different medical issues, particularly:

  • Congestive coronary heart failure
  • Solid pulmonale (coronary heart situation)
  • A fever of 102 levels Fahrenheit or extra for 24 hours or extra
  • Hypothyroidism (inactive thyroid) or
  • An infection, extreme (instance: sepsis)
  • Kidney illness in infants lower than Three months
  • Liver illness (instance: cirrhosis, hepatitis)
  • Pulmonary edema (lung situation)
  • Shock (a critical situation with little or no blood circulate within the physique) – use treatment with warning. Results could improve because of slower disposal of medication from the physique.
  • Coronary heart rhythm problems (instance: arrhythmias)
  • Seizures, or historical past
  • Abdomen ulcer — use with warning. Perhaps utilizing this medication could make your situation worse.


What ought to I do in an emergency or overdose?

In instances of emergency or overdose, contact your native emergency companies supplier (119) or instantly to the closest hospital emergency division.

Signs of an aminophylline overdose embody nausea, vomiting, headache, insomnia, tremors (shaking or jerking of palms), restlessness, convulsions, and irregular heartbeat.

What ought to I do if I miss a dose?

When you neglect one dose of this medication, take it as quickly as attainable. Nonetheless, when it’s nearing the following dose, skip the missed dose and return to the same old dosing schedule. Don’t double the dose.

Good day Well being Group doesn’t present medical recommendation, prognosis or remedy.

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