This product mixture comprises two medicine: lopinavir and ritonavir. This product is used with different HIV medicine to assist management HIV. This drug helps scale back HIV ranges within the physique in order that the immune system can work higher. This can scale back the prospect of getting HIV issues (equivalent to new infections, most cancers) and enhance your high quality of life. Lopinavir and ritonavir belong to a category of medicine often known as HIV protease inhibitors. Ritonavir will increase lopinavir ranges thereby serving to to work higher lopinavir.
Lopinavir / ritonavir will not be a treatment for HIV an infection. To scale back the chance of spreading HIV to others, do the entire following: (1) proceed to make use of all HIV medicine precisely as prescribed by the physician, (2) at all times use efficient contraceptive strategies (latex or polyurethane condoms / dental dams) for all sexual exercise, and (3) don’t share private gadgets (equivalent to needles / syringes, toothbrushes and razors) which will have been uncovered to blood or different bodily fluids. Seek the advice of a physician or pharmacist for extra particulars.
OTHER USES: This part comprises the usage of this drug which isn’t listed on an authorized label, however could also be prescribed by your well being care skilled. Use this medication for the situations listed beneath provided that it has been prescribed by your physician and well being skilled. This product will also be used along side different HIV medicine to scale back the chance of contracting HIV an infection after contact with the virus. Seek the advice of your physician for extra particulars.
Take this medication with or with out meals based on physician's instructions, normally a couple of times a day. Swallow tablets instantly. Don’t crush or chew the pill. The dosage relies in your medical situation, response to medicine and different drugs you’re taking. Remember to inform your physician and pharmacist all of the merchandise you’re utilizing (together with prescription, non-prescription medicine and natural merchandise). For kids, dosage primarily based on age, weight and peak. A once-daily dose will not be advisable for youngsters underneath 18 years. When you eat didanoside for this product, you possibly can drink it concurrently this product however don't take it with out consuming.
You will need to proceed taking this drug (and different HIV medicine) precisely as prescribed by the physician. Don’t miss any dose. This medication works greatest when the quantity of medicine in your physique is saved at a relentless degree. Due to this fact, take this medication at balanced intervals. That can assist you bear in mind, drink on the identical time day-after-day. Don’t eat kind of than advisable or cease taking it (or different HIV medicine) even for a short while except directed by a physician. This could trigger the quantity of virus to extend, making an infection tougher to deal with or worse uncomfortable side effects.
You may retailer the drugs within the fridge till the expiration date printed on the label, or you possibly can retailer it at room temperature for as much as 2 months. Don’t retailer within the rest room. Don't freeze it. Different manufacturers of this drug could have completely different storage guidelines. Observe the storage directions on the product packaging or ask your pharmacist. Preserve all medicines out of the attain of kids and pets.
Don’t flush medication in the bathroom or within the sewer except instructed. Discard this product when it has expired or whether it is not wanted. Seek the advice of your pharmacist or native waste disposal firm about the right way to safely eliminate your product.
The data offered will not be an alternative choice to medical recommendation. ALWAYS seek the advice of your physician or pharmacist earlier than beginning therapy.
Comply with the physician's recommendation or the dosage directions offered on the drugs packaging.
Uncomfortable side effects
Search fast medical consideration should you expertise any of the next indicators of an allergic response: hives, issue respiratory, swelling of the face, lips, tongue, or throat.
Cease utilizing this medication and phone your physician should you expertise any of the next severe uncomfortable side effects:
Kepala headache accompanied by chest ache and dizziness, fainting, speedy coronary heart palpitations or palpitations
⇒ imaginative and prescient adjustments
⇒ elevated urination or excessive thirst
Penis painful erection of the penis or lasting greater than four hours
⇒ indicators of a brand new an infection, equivalent to fever or chills, cough, or flu signs
⇒ sweating, hand tremors, anxiousness, irritability, sleep issues (insomnia)
⇒ diarrhea, unexplained weight reduction, menstrual adjustments, impotence, lack of curiosity in intercourse
⇒ swelling within the neck or throat (enlarged thyroid)
⇒ muscle weak spot, fatigue, joints or muscle aches, shortness of breath
⇒ issues when strolling, respiratory, speaking, swallowing, or transferring the eyes
⇒ prickly feeling in fingers or toes, extreme decrease again ache, lack of bladder
Parah extreme ache within the higher stomach spreading to the again, nausea and vomiting
⇒ lack of urge for food, itching, darkish urine, darkish stools, jaundice (yellowing of the pores and skin or eyes)
Parah extreme pores and skin reactions – fever, sore throat, swelling within the face or tongue, burning in your eyes, pores and skin ache, adopted by a purple or purple pores and skin rash that spreads (particularly on the face or higher physique) and blisters or peeling.
Not so severe uncomfortable side effects embody:
⇒ delicate nausea, vomiting, stomach ache
⇒ delicate pores and skin rash
⇒ adjustments within the form or location of physique fats (particularly in your arms, legs, face, neck, chest, and waist).
Not everybody experiences these uncomfortable side effects. There could also be some uncomfortable side effects not listed above. When you’ve got considerations about uncomfortable side effects, please seek the advice of a physician or pharmacist.
Prevention & Warnings
Earlier than utilizing this drug, inform your physician in case you are allergic to lopinavir, ritonavir (ritonavir), one other drug, or one of many elements in lopinavir and ritonavir tablets. Ask the pharmacist for a listing of elements. Inform your physician in case you are taking any of the next medicine: alfuzosin (Uroxatral) cisapride (Propulsid) (not out there S). Ergot drugs equivalent to dihydroergotamine (DHE 45, Migranal), ergonovine, ergotamine (Ergomar, in Cafergot, in Migergotamine) ), and methylergonovine (Methergine) lovastatin (Altoprev, Mevacor, in Advicor) midazolam (Versed) pimozide (Orap) rifampin (Rimactane, Rifadin, in Rifamate, in Rifater) sildenafil simvastatin (Simcor, Zocorion or Vocolion) ). Your physician could let you know to cease taking lopinavir and ritonavir should you take one among these medicine.
Inform your physician in case you are taking prescription or non-prescription medicine, natural dietary supplements, or nutritional vitamins. Don't neglect to say: anticoagulants ('blood thinners') equivalent to warfarin (Coumadin) antifungals equivalent to itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend) atovaquone (Mepron, in Malarone) beta-blockers bocepreviran (Victrelis) boss Tracleer) bupropion (Wellbutrin, Zyban) calcium-channel blockers equivalent to felodipine, nicardipine (Cardene), and nifedipine (Adalat, Procardia) ldl cholesterol medicine equivalent to atorvastatin (Lipitor), and rosuvastatin (Crestor) clarithromycin (Biaxin) colchicine) (Lanoxin) fentanyl (Actiq, Duragesic, Onsolis) fluticasone (Advair, in Flovent) fosamprenavir (Lexiva) most cancers medicine equivalent to dasatinib (Sprycel), nilotinib (Tasigna). vinblastine, and vincristine cardiac medicine equivalent to amiodarone (Cordarone, Pacerone), lidocaine, and quinidine (Quinidex) seizure-suppressing medicine equivalent to carbamazepine (Equetro, Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin) immunosuppressive medicine (cyclosporine equivalent to cyclosporine (cyclos) Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf) methadone (Dolophine) oral steroids equivalent to dexamethasone (Decadron, Dexone) antiviral medicine equivalent to abacavir (Ziagen, in Epzicom, in Trizivir) orzanavir (Reyataz), delaviorine (delaviorine) (delaviorine)) , efavirenz (Sustiva), indinavir (Crixivan), maraviroc (Selzentry), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), tenofovir (Viread, in Atripla, in Truvada), tipranavir (Aptivus), saquinavir (saquinavir) ), and zidovudine (Retrovir, Combivir, Trizivir) rifabutin (Mycobutin) salmeterol (Serevent, Advair) sildenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) sulfenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) sulfenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) sulfenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) disulfiram methylid (Antaboleid) . Your physician can monitor your dosage. When you take didanoside drink 1 hour earlier than or 2 hours after taking lopinavir and ritonavir with meals. When you take lopinavir and ritonavir tablets, you possibly can take them on an empty abdomen along with didanoside. Inform the physician which natural merchandise you’re utilizing, particularly merchandise that include St. John's wort. You shouldn’t take St. John's wort throughout therapy with lopinavir and ritonavir.
Inform your physician you probably have or have had an extended QT interval (a uncommon coronary heart downside that may trigger irregular heartbeats, fainting, or sudden demise), irregular heartbeat, low blood potassium ranges, hemophilia, excessive ldl cholesterol or triglycerides (fats ) within the blood, pancreatitis (pancreatic swelling), or coronary heart or liver illness. lopinavir and ritonavir scale back the effectiveness of hormonal contraception (contraception capsules, patches, rings, or injections). Discuss to your physician about the right way to use different types of contraception that you need to use. Inform your physician in case you are pregnant, planning to grow to be pregnant, or breastfeeding. When you grow to be pregnant whereas taking lopinavir and ritonavir, name your physician. Don’t breastfeed in case you are contaminated with HIV or should you take lopinavir and ritonavir.
It’s best to know that sure elements in lopinavir and ritonavir options could cause severe and life-threatening uncomfortable side effects in newborns. Lopinavir and ritonavir oral options shouldn’t be given to full-term infants youthful than 14 days or untimely infants youthful than the final 14 days of their authentic due date, except medical doctors suppose there’s a good purpose for infants to obtain the fitting medicine after delivery. In case your child's physician chooses to offer your child lopinavir and a ritonavir answer instantly after delivery, your child will probably be fastidiously monitored for indicators of great uncomfortable side effects. Contact your child's physician instantly in case your child could be very sleepy or has a change in respiratory throughout his therapy with lopinavir and an oral ritonavir answer.
Physique fats can enhance or transfer to different areas of the physique such because the higher again, neck, breasts, and across the stomach. You may even see lack of physique fats from the face, legs and arms. You may expertise hyperglycemia (a rise in your blood sugar ranges), even should you don't have already got diabetes. Inform your physician straight away you probably have the next signs if you take lopinavir and ritonavir: excessive thirst, frequent urination, excessive starvation, blurred imaginative and prescient. You will need to contact a physician instantly after having these signs, as a result of untreated excessive blood sugar could cause a severe situation known as ketoacidosis. Ketoacidosis could be life-threatening if not handled at an early stage. Signs of ketoacidosis embody: dry mouth, nausea and vomiting, shortness of breath, fruity breath, and decreased consciousness. When taking medication to deal with HIV an infection, your immune system could get stronger and begin combating different infections which are already in your physique. This could trigger signs to develop from an infection. When you’ve got new signs or worsen after beginning therapy with lopinavir and ritonavir, make sure to inform your physician.
There is no such thing as a sufficient analysis on the dangers of utilizing this drug in pregnant or nursing girls. At all times seek the advice of a physician to contemplate the potential advantages and dangers earlier than utilizing this medication.
This drug is included within the threat of being pregnant class C based on the US Meals and Medication Administration (FDA). The next are references to being pregnant threat classes based on the FDA:
- A = No threat,
- B = No threat in a number of research,
- C = Possibly dangerous,
- D = There’s optimistic proof of threat,
- X = Contraindications,
- N = Unknown
Nursing moms mustn’t take this medication. Although the child will not be contaminated with HIV, it may be transmitted via breast milk
Drug interactions can change the efficiency of your medicine or enhance the chance of great uncomfortable side effects. Not all attainable drug interactions are listed on this doc. Preserve a listing of all of the merchandise you utilize (together with prescription / nonprescription medicines and natural merchandise) and seek the advice of your physician or pharmacist. Don’t begin, cease or change the dose of any drug with out the physician's approval.
- disulfiram (Antabuse)
- salmeterol with or with out fluticasone
- an antibiotic – clarithromycin, metronidazole, rifabutin
- an antidepressant – bupropion, trazodone
- Antifungal medicine equivalent to itraconazole, ketoconazole, voriconazole
- blood thinners equivalent to rivaroxaban, warfarin, Coumadin
- most cancers drug
- ldl cholesterol medicine equivalent to atorvastatin, rosuvastatin
- drugs for pulmonary arterial hypertension avanafil, sildenafil (Viagra), tadalafil, vardenafil
- coronary heart or blood strain drugs equivalent to amiodarone, felodipine, lidocaine, nicardipine, nifedipine, quinidine
- hepatitis C drug boceprevir or telaprevir
- medication to keep away from organ rejection of transplants
- narcotic medicine – fentanyl, methadone
- different HIV AIDS medicine equivalent to efavirenz, nevirapine, nelfinavir
- seizure medicine – carbamazepine, phenobarbital, phenytoin, valproic acid or
- steroid medicine equivalent to budesonide, dexamethasone, fluticasone, prednisone.
Sure medicines shouldn’t be used when consuming or at round meal instances for sure meals or meals as a result of drug interactions can happen. Consuming alcohol or tobacco with sure medicine may also trigger interactions to happen. Talk about your use of medicine with meals, alcohol, or tobacco along with your well being care supplier.
The presence of different medical issues can have an effect on the usage of this drug. Be sure to inform your physician you probably have different medical issues.
- diabetes mellitus
- hemophilia bleeding downside)
- hyperglycemia (hypertension)
- hyperlipidemia (hypertension, excessive fats)
- liver issues (hepatitis B or C)
- shortness of coronary heart
- coronary heart failure (cardiomyopathy, ischemic coronary heart illness)
- different coronary heart issues
- hypokalemia (low potassium) – watch out as a result of it may possibly enhance the chance.
What ought to I do in an emergency or overdose?
In circumstances of emergency or overdose, contact the native emergency providers supplier (112) or instantly to the closest hospital emergency division.
What ought to I do if I miss a dose?
When you neglect one dose of this medication, take it as quickly as attainable. However when it’s nearing the following dose, skip the missed dose and return to the same old dosage schedule. Don’t double the dose.
Whats up Well being Group doesn’t present medical recommendation, prognosis or therapy.