Nifedipine – A-Z Medication


What's nifedipine for?

Nifedipine is a drug with a perform to forestall sure varieties of chest ache (angina). This drug permits you to train extra and cut back the frequency of angina assaults. Nifedipine belongs to a category of medicines often known as calcium channel blocker. This drug works by stress-free the blood vessels in order that blood can movement extra simply. This drugs have to be used frequently to be efficient. This drug shouldn’t be used to deal with assaults of chest ache when it happens. Use different medicines (equivalent to sublingual nitroglycerin) to alleviate chest ache assaults as your physician recommends. Seek the advice of your physician and pharmacist for extra info.

Aged folks ought to talk about the dangers and advantages of this drug with a health care provider or pharmacist, and different options to nifedipine which are extra frequent (equivalent to a protracted response pill).

OTHER USES: This part incorporates using this drug which isn’t listed on an accredited label, however could also be prescribed by your well being care skilled. Use this drugs for the situations listed under provided that it has been prescribed by your physician and well being skilled.

This drug may also be used to deal with sure blood movement problems (Raynaud's syndrome).

The dose of nifedipine and the unwanted side effects of nifedipine can be defined additional under.

The right way to use nifedipine?

Use this drugs by taking it in keeping with your physician's recommendation, often 3 times a day at supper time or not, as your physician recommends. Swallow this drug in a single piece, don’t grind, chew, or destroy the capsule.

The dosage will depend on well being situations and response to therapy.

Your physician might improve your dose regularly. Comply with the physician's directions nicely.

Keep away from it grapefruit or drink juice grapefruit when utilizing this drugs until your physician or pharmacist permits it. Grapefruit can improve sure drug ranges in your bloodstream. Ask your physician or pharmacist for extra info.

Use this treatment frequently to get the specified outcomes. That can assist you bear in mind to make use of it on the identical time on daily basis.

Let your physician know in case your situation is getting worse (for instance, your chest ache is getting worse or is rising in frequency).

How is nifedipine saved?

This drug is greatest saved at room temperature, away from direct gentle and damp locations. Don’t retailer within the lavatory. Don't freeze it. Different manufacturers of this drug might have completely different storage guidelines. Observe the storage directions on the product packaging or ask your pharmacist. Hold all medicines out of the attain of youngsters and pets.

Don’t flush drugs in the bathroom or within the sewer until instructed. Discard this product when it has expired or whether it is not wanted. Seek the advice of your pharmacist or native waste disposal firm about learn how to safely get rid of your product.


The data offered will not be an alternative to medical recommendation. ALWAYS seek the advice of your physician or pharmacist earlier than beginning therapy.

What’s the dose of nifedipine for adults?

Dosage for Hypertension in Adults

Preliminary dose:
Prolonged launch tablets: 30 to 60 mg orally as soon as a day
The dose may be elevated regularly each 7 to 14 days.

Dosage for Migraine Prophylaxis in Adults

Preliminary dose:
Prolonged launch tablets: 30 mg orally as soon as a day
Speedy capsule launch: 10 mg orally three occasions a day

Dosage for Angina Pectoris Prophylaxis in adults

Preliminary dose:
Prolonged launch tablets: 30 to 60 mg orally as soon as a day
Speedy capsule launch: 10 mg orally three occasions a day
Upkeep dose:
Speedy launch capsules: 10 to 30 mg orally three to four occasions a day

Dosages for Congenital Coronary heart Failure in Adults

Preliminary dose:
Procardia XL (R): 30 to 60 mg orally as soon as a day
Adalat (R) CC: 30 mg orally as soon as a day

Doses for Untimely Births in Adults

The flexibility of tocolitis from nifedipine has been evaluated in a number of research. Doses used within the examine vary from 10 to 20 mg each 6 to eight hours as wanted and are tolerated to delay supply.

What’s the dose of nifedipine for kids?

Doses for Emergency Hypertension in Youngsters

Speedy capsule launch: 0.25 to 0.5 mg / kg / dose (most 10 mg / dose) repeated each four to six hours if wanted
Most dose: 1 to 2 mg / kg / day

Doses for Hypertension in Youngsters

Pill prolonged launch:
Youngsters: 0.25 to 0.5 mg / kg / day divided into 1 to 2 doses; dosage have to be titrated for impact.

Most dose: three mg / kg / day as much as 120 mg / day (or 180 mg / day in sure locations)

Doses for Hypertrophic Cardiomyopathy in Youngsters

Youngsters: 0.6 to 0.9 mg / kg / 24 hours divided into three or four doses

In what dose is nifedipine accessible?

Tablets, ER: 30 mg, 60 mg, 90 mg

Capsules, oral: 10 mg

Uncomfortable side effects

What unwanted side effects may be skilled attributable to nifedipine?

Search emergency assist instantly for those who expertise any of the next indicators of an allergic response: rash; issue respiratory; swelling of the face, lips, tongue, or throat.

Contact your physician instantly for those who expertise severe unwanted side effects equivalent to:

  • worsening angina
  • extreme constipation and cramps, extreme stomach ache or heartburn, coughing up blood
  • feeling such as you need to cross out
  • really feel issue respiratory, swelling of the arms or ft
  • a quick, quick heartbeat
  • numbness or tingling
  • jaundice (yellowing eyes and pores and skin)
  • chest ache or extreme feeling, ache that radiates to the arms and shoulders, nausea, sweating, feeling unwell

Much less severe unwanted side effects embrace:

  • headache, dizziness
  • drowsiness, feeling drained
  • nausea, constipation, diarrhea, or gentle stomachache
  • sleep problems (insomnia)
  • gentle itching or rashes
  • joint ache, cramps within the legs
  • really feel heat, tingling, or redness in your pores and skin
  • extra frequent urination

Not everybody experiences the above unwanted side effects. There could also be some unwanted side effects not talked about above. If in case you have issues about sure unwanted side effects, seek the advice of your physician or pharmacist.

Prevention & Warnings

What must be identified earlier than utilizing nifedipine?

Earlier than utilizing Nifedipine,

  • inform your physician when you have an allergy to nifedipine, different medicines, or any composition within the nifedipine product that’s prescribed. Ask your pharmacist for a listing of compositions
  • inform your physician and pharmacist what prescription and prescription medicines, nutritional vitamins, therapies and natural merchandise you’re taking or plan to take. Ensure you point out the next medicines: acarbose (Prandase, Precose); anticoagulants (‘blood thinners’) equivalent to warfarin (Coumadin, Jantoven); antifungals equivalent to fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); beta blockers equivalent to atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal), and timolol (Blocadren); carbamazepine (Carbatrol, Epitol, Tegretol); cimetidine (Tagamet); digoxin (Lanoxin, Lanoxicaps); diltiazem (Cardizem); doxazosin (Cardura); erythromycin (E.E.S., E-Mycin, Erythrocin); fentanyl (Actiq, Duragesic, Fentora, Sublimaze); flecainide (Tambocor); HIV protease inhibitors equivalent to amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); metformin (Glucophage); nefazodone; phenobarbital (Luminal); phenytoin (Dilantin, Diphenylan Sodium); quinidine (Quinidex); quinupristin and dalfopristin (Synercid); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); rifapentine (Priftin); tacrolimus (Prograph); valproic acid (Depakene, Depakote); and verapamil (Calan, Covera, Isoptin, Verelan). Your physician may have to alter the dosage of treatment or watch you for unwanted side effects
  • inform your physician in regards to the natural merchandise you’re utilizing, particularly St. John’s Wort.
  • inform your physician when you have or have had a narrowing or blockage of the digestive system or different situations that trigger slower meals digestion; or coronary heart, liver, or kidney illness. Additionally inform your physician when you have skilled a myocardial an infection prior to now 2 weeks
  • inform your physician in case you are pregnant, planning a being pregnant, breastfeeding. In case you turn out to be pregnant whereas utilizing nifedipine, contact your physician
  • Seek the advice of your physician in regards to the security of utilizing nifedipine capsules in case you are aged 65 years and over. The aged usually are not suggested to make use of nifedipine capsules as a result of they don’t seem to be as protected as different medication that can be utilized to deal with the identical situation.
  • for those who do surgical procedure, together with dental surgical procedure, inform your physician or dentist that you’re utilizing nifedipine
  • Ask your physician in regards to the security of utilizing alcoholic drinks when utilizing nifedipine. Alcohol can worsen the unwanted side effects of nifedipine.

Is nifedipine protected for pregnant and lactating girls?

There isn’t a satisfactory analysis on the dangers of utilizing this drug in pregnant or nursing girls. At all times seek the advice of your physician to contemplate the potential advantages and dangers earlier than utilizing this drugs. This drug is included within the class C being pregnant danger in keeping with the US Meals and Medicine Administration (FDA)

The next are references to being pregnant danger classes in keeping with the FDA:

  • A = No danger,
  • B = No danger in some research,
  • C = Possibly dangerous,
  • D = There’s constructive proof of danger,
  • X = Contraindications,
  • N = Unknown

Nifedipine can cross by way of breast milk and may be dangerous to nursing infants. Let your physician know in case you are breastfeeding.


What medicines may work together with nifedipine?

Drug interactions can change the best way medication work or improve your danger for severe unwanted side effects. This doc doesn’t embrace all drug interactions that may happen. Hold a listing of the merchandise you utilize (together with prescription / nonprescription medicines and natural merchandise) and inform your physician and pharmacist. Don’t begin, cease or change the dose of any drugs with out your physician's data.

Earlier than utilizing this drugs, inform your physician or pharmacist about all of the prescription and non-prescription medication and natural merchandise that you’re utilizing, particularly these containing:

Phenytoin, quinidine, tacrolimus.

Different medication can have an effect on the removing of nifedipine out of your physique, which may have an effect on the efficiency of nifedipine. Examples embrace cimetidine, azole antifungals (equivalent to triraconazole), macrolide antibiotics (equivalent to erythromycin), rifamycins (such asrifabutin), St. John’s wort, medication used to deal with seizures (equivalent to carbamazepine), and others.

Examine the labels of all of your medicines (equivalent to chilly and cough merchandise, food plan medication) as a result of they’ll comprise components that may improve coronary heart price and worsen chest ache (together with caffeine, pseudoephedrine, and phenylephrine). Ask your pharmacist about utilizing this product safely.

Cimetidine is a non-prescription drug that’s used to deal with extra abdomen acid, as a result of cimetidine can work together with nifedipine, ask the pharmacist about different merchandise that may deal with extra abdomen acid.

Can meals or alcohol work together with nifedipine?

Sure medicines shouldn’t be used when consuming or when consuming sure meals as a result of drug interactions can happen. Consuming alcohol or tobacco with sure medication may trigger interactions to happen. Talk about your use of medicine with meals, alcohol, or tobacco together with your well being care supplier.

What well being situations can work together with nifedipine?

Different well being issues can have an effect on using this drug. Let your physician know when you have different well being issues, particularly:

  • aortic stenosis (narrowing of the valve to the guts)
  • heavy digestive tract blockage
  • congenital coronary heart failure
  • coronary heart assault
  • hypotension (low blood stress) – use with warning. Can improve severe unwanted side effects.
  • cardiogenic shock (shock attributable to a coronary heart assault) – shouldn’t be utilized in sufferers with this situation
  • galactose intolerance (uncommon hereditary illness)
  • Lapp lactase deficiency (uncommon hereditary illness) —the prolonged launch pill of this drug incorporates lactose (milk sugar), and shouldn’t be given to sufferers with this situation
  • kidney downside
  • liver issues (together with cirrhosis) – use with warning. The impact of nifedipine may be elevated attributable to slower drug launch from the physique.


What ought to I do in an emergency or overdose?

In instances of emergency or overdose, contact the native emergency providers supplier (112) or instantly to the closest hospital emergency division.

Signs of overdose may be signs of hypoglycemia and the next:

  • dizzy
  • quick coronary heart price
  • pores and skin is purple and feels heat
  • fidgety
  • nausea
  • gag
  • swelling of the arms, ft, ankles or calves
  • blurred imaginative and prescient
  • handed out

What ought to I do if I miss a dose?

In case you neglect one dose of this drugs, take it as quickly as potential. However when it’s nearing the following dose, skip the missed dose and return to the standard dosage schedule. Don’t double the dose.

Hey Well being Group doesn’t present medical recommendation, prognosis or therapy.

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