Aminophylline – A-Z Medicine



What is the drug Aminophylline used for?

Aminophylline is a medicine to treat cough and difficulty breathing due to prolonged lung disease (for example asthma, emphysema, and chronic bronchitis).

Aminophylline belongs to a class of drugs called xanthine. This drug works in the airways by relaxing muscles, opening airways to restore breathing, and reducing the lung's response to foreign substances.

This drug does not work right away and should not be used for sudden onset of respiratory distress. Your doctor should prescribe medication or instant suckers (such as albuterol) for sudden shortness of breath or asthma while you are using this medicine.

You should always carry this instant sucker everywhere. Consult a doctor or pharmacist for further details.

What are the rules for using Aminophylline?

Aminophylline can be taken before or after meals. This medicine is usually taken 2-4 times or according to doctor's directions. If this medicine makes you sick to your stomach, you can take it with food.

Do not crush or chew the extended tablets because they can release all drugs at one time, which increases the risk of side effects.

Also, do not split the tablet if it does not have a dividing line on the drug, or if the doctor or pharmacist does not tell you to do so. You can swallow or divide a tablet without breaking or chewing it first.

The dosage for this drug is determined based on medical conditions, response to therapy, age, body weight, blood drug levels, and other drugs that you may be taking.

Use this medicine regularly to get maximum results. To help you remember, drink it at the same time every day. Tell your doctor if your condition doesn't improve or it gets worse.

How to store Aminophylline?

Store medication at room temperature, away from exposure to light and moisture. Do not store in the bathroom and do not freeze. Drugs with different brands may have different ways of storing.

Check the product box for instructions on how to store it, or ask the pharmacist. Keep medication away from children and pets.

Do not flush medicine in the toilet or throw it into the drain if not told to. Dispose of this product properly if it is past the due date or you no longer need it.

Consult with a pharmacist or local waste disposal agency for more in-depth details on how to safely dispose of the product.


The information provided is not a substitute for medical advice. ALWAYS consult a doctor or pharmacist before starting treatment.

What is the dose of Aminophylline for adults?

Intravenous (IV): all doses based on aminophylline — patients not receiving aminophyline or theophylline

  • Initial dose (Loading dose): 6 mg / kg in 100-200 mL IV fluid by infusion once in 20-30 minutes.
  • Maintenance dose (after initial dose):
  • Healthy adults who do not smoke: 0.7 mg / kg / hour continuous intravenous infusion.
  • Young adult smokers: 0.9 mg / kg / hour continuous intravenous infusion.
  • Patients with cor pulmonale or congestive heart failure: 0.25 mg / kg / hour continuous intravenous infusion.

Oral: Patients who do not receive aminophylline or theophylline

  • Initial dose (Loading Dosage): 6.3 mg / kg orally.
  • Maintenance dose: (after initial dose):
  • Healthy adults who don't smoke: 12.5 mg / kg / day in separate doses. Do not exceed 1,125 mg / day.
  • Young adult smokers: 19 mg / kg / day in separate doses.
  • Patients with cor pulmonale or congestive heart failure: 6.25 mg / kg / day in separate doses. Do not exceed 500 mg / day.

What is the dose of Aminophylline for children?

Children's dose for premature apnea

Infants 4 weeks and over: (IV or oral, all doses based on aminophylline):
  • Initial dose (Loading dose): (Patients who do not receive aminophylline or theophylline): 5-6 mg / kg once – if diluted in IV fluids and given intravenously once for 20-30 minutes.
  • Maintenance dose: 3-8 mg / kg / day apart every 6-12 hours

Children's dosage for acute asthma

IV: (all doses based on aminophylline and patients not receiving aminophylline or theophylline):
  • Initial dose (Loading dose) for healing asthma: 6 mg / kg diluted in IV fluids by infusion once for 20-30 minutes.
  • Maintenance dose (after administration dose):
  • 6 weeks-6 months: 0.5 mg / kg / hour continuous intravenous infusion.
  • 6 months-1 year: 0.6-0.7 mg / kg / hour continuous intravenous infusion.
  • 1-9 years: 1-1.2 mg / kg / hour continuous intravenous infusion.
  • 9-12 years: 0.9 mg / kg / hour continuous intravenous infusion.
  • > 12 years: 0.7 mg / kg / hour continuous intravenous infusion.
Oral: (Patients who do not receive aminophylline or theophylline):
  • Initial dose (Loading dose): 6.3 mg / kg orally.
  • Maintenance dose (after administration dose):
  • 42 – 182 days: 12-13.5 mg / kg / day in separate doses.
  • 6 – 12 months: 15-22.5 mg / kg / day in separate doses.
  • 1 – 9 years: 25-30 mg / kg / day in separate doses.
  • 9-12 years: 17-20 mg / kg / day in separate doses.
  • 12-16 years: 15-17 mg / kg in separate doses.
  • 16 years and over: 6.25-20 mg / kg in separate doses.

In what dosages and preparations is Aminophylline available?

This drug is available in injection solutions and tablets: 105 mg / 5 ml.

Side effects

What side effects might occur due to Aminophylline?

If you experience the following serious side effects, stop using aminophylline and seek immediate medical attention:

  • Allergic reaction (difficulty breathing, narrowing of the throat, swelling of the lips, tongue, or face or itching)
  • Convulsions
  • Increased or irregular heartbeat or
  • Severe nausea or vomiting.
  • Chest pain

Other milder side effects may also occur, although they rarely occur at the right dose. Continue to take aminophylline and talk with your doctor if you experience:

  • Mild nausea, decreased appetite, or decreased body weight
  • Restlessness, trembling, or insomnia
  • Headache, fainting, or dizziness.
  • The amount of urine increases

There are also side effects that do not require medical assistance, because they disappear over time as you adapt to this medication, including:

  • Mild headache
  • Easy to get angry
  • Insomnia, could not even sleep at all
  • Always feeling less rested

Not everyone experiences the side effects mentioned. There may be some side effects not mentioned above. If you experience concerns about certain side effects, consult your doctor or pharmacist.

Prevention & Warnings

What must be known before using Aminophylline?

Before using this medicine to cure asthma, tell your doctor and pharmacist:

  • If you are allergic to aminophylline or other drugs
  • Regarding the list of prescription drugs that you are currently taking, especially
    • allopurinol (Zyloprim)
    • azithromycin (Zithromax)
    • carbamazepine (Tegretol)
    • cimetidine (Tagamet)
    • ciprofloxacin (Cipro)
    • clarithromycin (Biaxin)
    • diuretic (water pill ’)
    • erythromycin
    • lithium (Eskalith, Lithobid)
    • oral contraceptives
    • phenytoin (Dilantin)
    • prednisone (Deltasone)
    • propranolol (Inderal)
    • rifampin (Rifadin)
    • tetracycline (Sumycin)
    • other medicines for infection or heart disease.
  • Understanding prescription and non-prescription drugs that you are currently taking, especially over-the-counter drugs that contain ephedrine, epinephrine, phenylephrine, phenylpropanolamine, or pseudoephedrine. Many over-the-counter medications contain these drugs (such as diet pills and cold and asthma medications), so check the labels carefully. Do not take this medicine without talking to a doctor because it can increase the side effects of aminophylline.
  • If you have or have had a seizure, heart disease, thyroid gland too or completely inactive, high blood pressure, or liver disease or you have a history of alcohol abuse.
  • If you are pregnant, planning to become pregnant, or breastfeeding. If you become pregnant while using aminophylline, call your doctor.
  • If you use tobacco products. Smoking might affect the mechanism of action of aminophylline in your body.

Is Aminophylline safe for pregnant or nursing women?

Aminophylline absorption in your body might change if you are pregnant. However, in studies conducted on animals, in the amount of three times the recommended dosage for humans, no signs of defects were shown.

Even so, there is no adequate research on the risks of using this drug in pregnant or nursing women. Always consult your doctor to consider the potential benefits and risks before using this medicine.

This drug is included in the risk of pregnancy category C based on a category created by the US Food and Drug Administration (FDA).

Pregnancy risk categories according to the FDA:

  • A = No risk
  • B = No risk in several studies
  • C = Maybe risky
  • D = There is positive evidence of risk
  • X = Contraindications
  • N = Unknown

Meanwhile, aminophylline can enter breast milk and be able to affect the baby. Do not take aminophylline if you are breastfeeding without talking to your doctor beforehand if you are breastfeeding.


What medicines might interact with Aminophylline?

Drug interactions might change the way drugs work or increase the risk of serious side effects. This article does not cover all possible drug interactions with aminophylline.

Keep a list of all the medicinal products you use (including prescription / non-prescription drugs and herbal products) and notify the doctor and pharmacist. Do not start, stop or change the dosage of the drug without the doctor's approval.

  • Alcohol
  • Cimetidine (Tagamet, Tagamet HB)
  • Fluoroquinolone antibiotics such as enoxacin (Penetrex), lomefloxacin (Maxaquin), ciprofloxacin (Cipro), norfloxacin (Noroxin), and ofloxacin (Floxin)
  • Clarithromycin (Biaxin) and erythromycin (Ery-Tab, E.E.S., E-Mycin, etc.)
  • Disulfiram (Antabuse)
  • Estrogen (Ogen, Premarin and many other types)
  • Fluvoxamine (Luvox)
  • Methotrexate (Folex, Rheumatrex)
  • Mexiletine (Mexitil) and propafenone (Rythmol)
  • Propranolol (Inderal)
  • Tacrine (Cognex)
  • Ticlopidine (Ticlid) and
  • Verapamil (Verelan, Calan, Isoptin).

The following drugs may reduce aminophylline levels in the blood, which makes asthma more difficult to control:

  • Aminoglutethimide (Cytadren),
  • Carbamazepine (Tegretol),
  • Isoproterenol (Isuprel),
  • Moricizine (Ethmozine),
  • Phenobarbital (Luminal, Solfoton),
  • Phenytoin (Dilantin),
  • Rifampin (Rifadin), and
  • Sucralfate (Carafate).

Can food or alcohol interact with Aminophylline?

Certain medicines cannot be used when eating or when eating certain foods because drug interactions can occur.

Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Talk to a professional health care provider about using drugs with food, alcohol or tobacco.

What health conditions can interact with Aminophylline?

Other medical disorders may affect the use of drugs that can be used to treat bronchitis. Be sure to tell your doctor if you have other medical problems, specifically:

  • Congestive heart failure
  • Cast pulmonale (heart condition)
  • A fever of 102 degrees Fahrenheit or more for 24 hours or more
  • Hypothyroidism (inactive thyroid) or
  • Infection, severe (example: sepsis)
  • Kidney disease in infants less than 3 months
  • Liver disease (example: cirrhosis, hepatitis)
  • Pulmonary edema (lung condition)
  • Shock (a serious condition with very little blood flow in the body) – use medication with caution. Effects may increase due to slower disposal of drugs from the body.
  • Heart rhythm disorders (example: arrhythmias)
  • Seizures, or history
  • Stomach ulcer — use with caution. Maybe using this medicine can make your condition worse.


What should I do in an emergency or overdose?

In cases of emergency or overdose, contact your local emergency services provider (119) or immediately to the nearest hospital emergency department.

Symptoms of an aminophylline overdose include nausea, vomiting, headache, insomnia, tremors (shaking or jerking of hands), restlessness, convulsions, and irregular heartbeat.

What should I do if I miss a dose?

If you forget one dose of this medicine, take it as soon as possible. However, when it is nearing the next dose, skip the missed dose and return to the usual dosing schedule. Do not double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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