Avandamet is an oral drug consisting of a mix of two medicine, particularly rosiglitazone and metformin. Using Avandamet at the side of a food regimen and train program can assist management blood sugar ranges in sufferers with kind two diabetes. Controlling excessive blood sugar can assist forestall kidney harm, blindness, nerve issues, lack of limbs, and sexual operate issues. Good diabetes management may also assist scale back the danger of coronary heart assault and stroke.
Rosiglitazone and metformin contained in Avandamet scale back blood sugar by restoring your physique's response to insulin. Metformin additionally reduces sugar manufacturing by the liver and the quantity of sugar absorbed by the gut throughout the digestive course of.
Using Avandamet just isn’t meant to deal with sufferers with kind one diabetes. Avandamet can also be not really useful to be used at the side of insulin. Utilizing each collectively will improve the danger of great coronary heart issues.
What are Avandamet's ingesting guidelines?
Avandamet is an oral treatment that’s often taken a couple of times a day together with meals to keep away from abdomen ache. Regularly, your physician gives you a low dose first in the beginning of remedy and improve it progressively.
Don’t change the dose, cease or proceed remedy if it’s not really useful by your physician. The dosage given relies in your well being situation and your physique's response to remedy.
Take this treatment repeatedly to get most outcomes. To make it simpler so that you can bear in mind, take this drugs on the identical time day by day.
What are Avandamet's storage guidelines?
This drug is finest saved at room temperature not exceeding 30 levels Celsius. Keep away from storing this drugs from warmth and direct gentle. Don’t retailer this drugs in a moist place, reminiscent of the lavatory. Preserve out of attain of youngsters and pets.
Don’t flush or eliminate this drugs in the bathroom or the drain until instructed. Discard this product if it has expired or is now not wanted. Ask your native pharmacist or waste disposal firm about the best way to safely eliminate this product.
The data offered just isn’t an alternative choice to medical recommendation. ALWAYS seek the advice of your physician or pharmacist earlier than beginning remedy.
What’s the dose of Avandamet (rosiglitazone / metformin) for grownup sufferers?
- Preliminary dose: rosiglitazone 2 mg / metformin 500 mg, a couple of times a day
- If HbA1C is larger than 11% or fasting blood sugar exceeds 270 mg / dL, think about an preliminary dose of rosiglitazone 2 mg / metformin 500 mg, twice a day
- Improve the dose of rosiglitazone 2 mg / metformin 500 mg per day in divided doses if it stays uncontrolled after 4 weeks
In sufferers who’ve taken rosiglitazone:
Preliminary dose: swap to Avandamet with the identical dose rosiglitazone composition plus 1,000 mg of metformin per day, divided into two doses
In sufferers who’ve taken metformin:
Preliminary dose: swap to Avandamet with the identical dose of metformin plus rosiglitazone four mg per day, divided into two doses
In sufferers who’ve taken rosiglitazone and metformin as separate tablets:
Swap to Avandamet with the identical dose as every composition
Most day by day dose: rosiglitazone eight mg / metformin 2,000 mg per day
In what dosages and preparations is Avandamet (rosiglitazone-metformin) obtainable?
Tablets, Oral: 2 mg / 500 mg, four mg / 500 mg, 2 mg / 1,000 mg, four mg / 1,000 mg.
What unintended effects may happen resulting from consumption of Avandamet?
Nausea, abdomen ache, diarrhea, and sensations reminiscent of feeling metallic in your mouth might happen because of the consumption of this drug within the preliminary remedy interval. In case your abdomen complaints don't go away, contact your physician instantly. That might point out the prevalence of lactic acidosis resulting from consumption of an excessive amount of metformin.
Severe unintended effects that will happen resulting from consumption of Avandamet are, as follows:
- Modifications to your means to see
- Feeling drifted, as if it was about to fall
- Anemia, which is characterised by pale pores and skin, the top feels spinning or shortness of breath turns into shorter, speedy heartbeat, and issue concentrating
- Signs of a coronary heart assault, ache or stress within the chest, ache that radiates to the jaw or shoulder, nausea, sweating
- Indicators of coronary heart failure, reminiscent of shortness of breath even when mendacity down, swelling within the legs or ankles, speedy weight achieve
- Issues with the liver, that are characterised by nausea, vomiting, lack of urge for food, ache within the higher stomach, fatigue, darkish urine, pale stools, jaundice (on the pores and skin or eyes)
- Extreme pores and skin response, characterised by fever, laryngitis, swelling of the face or tongue, scorching eyes, ache on the floor of the pores and skin accompanied by a reddish-colored rash that spreads (particularly on the face and higher physique), pores and skin is injured and peeling off
The extra widespread unintended effects are:
Extreme allergic reactions are identified to happen not often resulting from the usage of this drug. Nevertheless, name your physician instantly if you happen to discover any indicators of allergic reactions reminiscent of rashes, itching, swelling of the face, eyes, lips, tongue, and throat, extreme dizziness, and shortness of breath.
The above checklist doesn’t embody all of the unintended effects that may happen resulting from consumption of Avandamet. Seek the advice of together with your physician about doable unintended effects that you’re nervous about can happen earlier than taking this drugs.
Warnings and Prevention
What ought to be thought-about earlier than taking Avandamet?
- Inform your physician in regards to the historical past of drug allergy you’ve got, particularly if you’re allergic to rosiglitazone and / or metformin, a glitazone class of medicine, reminiscent of pioglitazone or different drug allergic reactions
- Inform your physician about your medical historical past, together with diseases that you’ve or are at the moment affected by, particularly if in case you have kidney, liver illness, respiratory issues (extreme lung illness or bronchial asthma), coronary heart illness (coronary heart failure, assaults coronary heart, and angina), blood problems (anemia or vitamin B12 deficiency), swelling (edema), fluid within the lungs, abnormalities within the eyes, bone problems (reminiscent of osteoporosis)
- Earlier than performing an X-ray / CT scan operation or process that makes use of iodine-contrast fluid, inform your physician or dentist about utilizing this drugs. You might have to cease taking this drug if you’ll endure surgical procedure (together with dental surgical procedure) within the close to future
- Some folks might expertise lactic acidosis resulting from consumption of metformin. Contact your physician if you happen to discover situations that point out signs of lactic acidosis reminiscent of belly ache and nausea
- Using Avandamet can encourage ovulation and menstruation in ladies, even those that haven’t had the cycle for a very long time resulting from well being causes. This causes the possibility of an unplanned being pregnant taking place. Seek the advice of together with your physician about this if you wish to do start planning
- Inform your physician if you’re planning to grow to be pregnant or are pregnant. Your physician might recommend various therapies or regulate the dose relying on the trimester you take
Is Avandamet secure for pregnant and breastfeeding ladies?
There has not been ample analysis on the dangers to the fetus in pregnant ladies who eat Avandamet. Nevertheless, experiments performed on animals confirmed a threat to the fetus. United States POM, FDA, contains Avandamet in class C medicine (could also be dangerous).
The metformin contained in Avandamet is thought to exit along with breast milk, however it’s not but identified whether or not the identical factor additionally occurs with rosiglitazone. There are not any research that present that each will be dangerous for newborns. You’re really useful to not take this drugs when breastfeeding. Seek the advice of together with your physician about options that may be taken.
Drug interactions might change the way in which your treatment works or improve the danger of great unintended effects. Among the merchandise that work together with Avandamet are:
- Insulin or different diabetes oral medicines
- Drugs for coronary heart illness or blood stress management
- Ldl cholesterol-lowering medicine
The checklist might not embody all medicines or merchandise that may work together with Avandamet. Preserve a whole checklist of medicines that you just take and inform your physician, together with pharmaceuticals, meals stalls, nutritional vitamins, and natural medicines to stop the looks of drug interactions.
What ought to I do in an emergency or overdose?
Search rapid medical emergency help by calling 119 or instantly to the closest hospital emergency room. Severe signs that point out an overdose embody fainting and issue respiration.
What if I overlook my treatment schedule?
If you happen to overlook about your treatment schedule, take it as quickly as you bear in mind. Skip the missed dose whether it is approaching the following schedule. Proceed your dosage on an everyday schedule. Don’t double the dose to switch the missed dose at one time taking treatment.
Howdy Well being Group doesn’t present medical recommendation, analysis, or remedy.