Glimepiride – A-Z Medication

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Use

What’s the Glimepiride drug used for?

Glimepiride is among the oral remedy that belongs to the sulfonylureas.

This class of medicine works by decreasing blood sugar ranges within the physique by stimulating the physique to supply insulin.

This drug is often used to manage excessive blood sugar ranges in individuals with kind 2 diabetes. These medication may also be used with different diabetes drugs.

Controlling your blood sugar ranges can assist stop kidney injury, blindness, nerve issues, and sexual perform issues. Applicable diabetes management may also cut back the chance of coronary heart assault or stroke.

With a purpose to cut back blood sugar ranges within the physique, often you additionally must go on a nutritious diet and common train. These medication are included in pharmaceuticals so you may solely purchase them on the pharmacy in the event that they embody a prescription from a physician.

The best way to use Glimepiride?

As with different medication, there are procedures for utilizing glimepiride that you need to take note of when utilizing glimepiride, together with:

  • Probably the most applicable time to eat glimepiride is correct after breakfast as directed by your physician, often as soon as a day.
  • The dose of glimepiride given to you is the dose decided based mostly in your well being situation and your therapeutic response.
  • Often, the physician will give the bottom dose because the preliminary dose to then decide the suitable dose progressively.
  • For those who already use different antidiabetic medication (comparable to chlorpropamide), observe the directions given by your physician rigorously in an effort to cease your earlier antidiabetic remedy and begin utilizing glimepiride.
  • Colesevelam can cut back Glimepiride absorption. For those who use colesevelam, use Glimepiride not less than four hours earlier than utilizing it.
  • To get the utmost profit, use this medication on the identical time every single day.
  • Don't cease utilizing this medication with out the physician's approval, even in case you really feel wonderful.
  • It’s best to inform your physician in case your situation doesn’t enhance and even worsens (your blood sugar ranges rise or fall dramatically).

The best way to retailer Glimepiride?

There are procedures it’s best to take note of storing this medication correctly, as follows.

  • One of the best ways to retailer glimepiride is to maintain it at room temperature.
  • Avoid direct gentle or solar publicity.
  • Don’t retailer this medication in a moist place.
  • Don’t additionally retailer it within the rest room.
  • Don’t retailer and freeze within the freezer.
  • Different manufacturers of this drug could have totally different storage guidelines.
  • Observe the storage directions on the product packaging or ask your pharmacist.
  • Hold all medicines out of the attain of youngsters and pets.

Discard this product when it has expired or whether it is now not wanted. Don’t flush medication in the bathroom or within the sewer except instructed.

Don’t combine this medicinal waste with peculiar family waste for environmental well being. Seek the advice of the pharmacist or an officer out of your native waste disposal company about methods to safely eliminate your product.

Dose

The data supplied shouldn’t be an alternative choice to medical recommendation. ALWAYS seek the advice of your physician or pharmacist earlier than beginning therapy.

What’s the dose of Glimepiride for adults?

Grownup dose of kind 2 diabetes

  • Preliminary dose: 1-2 mg orally as soon as a day.
  • Remedy dose: Dosage could be elevated to 1-2 mg each 1-2 weeks, relying in your response to therapy.
  • Glimepiride needs to be given after breakfast or your first meal every single day
  • The really helpful most dose is eight mg per day.

Aged kind 2 diabetes

  • Preliminary dose: 1 mg orally as soon as a day.
  • Remedy dose: Dosage could be elevated to 1-2 mg each 1-2 weeks, relying in your response to therapy.

What’s the dose of Glimepiride for youngsters?

The dosage of using this drug for youngsters has not been decided. If you wish to give this medication to kids, ensure you seek the advice of your physician first.

In what dosages is Glimepiride obtainable?

Glimepiride is accessible within the following dosages.

Tablets, Oral: 1 mg, 2 mg, four mg

Uncomfortable side effects

What negative effects could be skilled because of Glimepiride?

As with different medicines, glimepiride additionally has negative effects that use medication that should be thought of. These negative effects could be labeled as delicate to severe. Uncomfortable side effects of utilizing glimepiride which are comparatively delicate are:

  • drowsiness, headache, fatigue
  • delicate nausea, vomiting, stomach ache, diarrhea
  • elevated sensitivity to daylight
  • delicate itching or pores and skin rash

In the meantime, fairly severe negative effects that may happen embody the next.

  • Indicators of allergic reactions comparable to hives, issue respiration; swollen face, lips, tongue, or throat
  • Extreme, itchy, crimson, or irritated pores and skin rashes
  • Pale pores and skin, simple bruising or bleeding, fever, the physique feels weak for no obvious motive
  • Numbness or tingling
  • Respiratory issues
  • The physique feels prefer to faint
  • Urine and stools are darkish in shade
  • Stomach ache within the higher half, delicate fever, jaundice (yellowing of the pores and skin or eyes)
  • Nausea, vomiting, no urge for food, feeling stressed, confused, hallucinations, muscle aches or weak point, and / or convulsions.

Not everybody experiences the next negative effects. There could also be some negative effects not talked about above. When you have considerations about sure negative effects that you just expertise after utilizing this medication, seek the advice of your physician or pharmacist.

Prevention & Warnings

What needs to be identified earlier than utilizing Glimepiride?

Earlier than you determine to make use of this medication, there are some things it’s best to learn about. These embody warning and stopping using glimepiride, together with:

  • Inform your physician and pharmacist if in case you have an allergy to glimepiride, different medication, or different components present in glimepiride. Ask the pharmacist for a listing of those components.
  • Inform your physician and pharmacist what prescription and nonprescription medication, nutritional vitamins, dietary dietary supplements, and natural merchandise you might be utilizing or plan to make use of.
  • Inform your physician in case you endure from or have suffered from G6PD deficiency (a hereditary situation that causes sooner crimson blood cell breakdown or hemolytic anemia); if in case you have hormonal abnormalities associated to adrenal, pituitary, or thyroid gland; or in case you endure from coronary heart, kidney or liver illness.
  • Inform your physician if you’re pregnant, planning to develop into pregnant, or are breastfeeding. If you will be pregnant and are at the moment utilizing this medication, contact your physician instantly.
  • If you will bear an operation, comparable to a dental surgical procedure or different main surgical procedure, inform your physician or dentist that you’re utilizing glimepiride.
  • Ask your physician whether or not it’s secure to make use of alcohol whereas beneath the affect of this drug. As a result of, alcohol can improve the chance of negative effects of drug use. Alcohol consumption whereas utilizing this drug may also trigger flushing (blushing), headache, nausea, vomiting, chest ache, weak point, blurred imaginative and prescient, psychological confusion, sweating, choking, issue respiration, and nervousness.
  • Keep away from pointless or extended solar publicity and put on protecting clothes, sun shades and sunblock. This medication could make your pores and skin delicate to daylight.
  • Ask your physician what to do if you’re sick, have an an infection or fever, expertise uncommon stress, or are injured. This situation can have an effect on blood sugar and the dosage of remedy that you just want.

Is Glimepiride secure for pregnant and breastfeeding ladies?

There isn’t any ample analysis on the dangers of utilizing this drug in pregnant or nursing ladies. At all times seek the advice of your physician to think about the potential advantages and dangers earlier than utilizing this medication. This drug is included within the class C being pregnant threat in accordance with the US Meals and Medication Administration (FDA) or equal to the Meals and Drug Supervisory Company (BPOM) in Indonesia. Following are references to being pregnant threat classes in accordance with the FDA:

  • A: No threat,
  • B: No threat in some research,
  • C: Possibly it's dangerous,
  • D: There may be optimistic proof of threat,
  • X: Contraindications,
  • N: Not identified

Interplay

What medicines may work together with glimepiride?

Drug interactions can change the efficiency of your remedy or improve the chance of significant negative effects. Not all doable drug interactions are listed on this article.

Hold a listing of all of the merchandise you utilize (together with prescription / nonprescription medicines and natural merchandise) and seek the advice of your physician or pharmacist. Don’t begin, cease or change the dose of any drug with out the physician's approval.

You’re extra susceptible to endure from hypoglycemia (low blood sugar) in case you use glimepiride with different medication that may decrease your blood sugar, together with:

  • anticoagulants (‘blood thinners’) comparable to warfarin (Coumadin);
  • aspirin and different nonsteroidal anti-inflammatory drugs (NSAIDs) comparable to ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn);
  • beta blockers comparable to atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal);
  • chloramphenicol;
  • clarithromycin (Biaxin);
  • disopyramide (Norpace);
  • diuretic (‘water pill’);
  • fluconazole (Diflucan);
  • fluoxetine (Prozac, Sarafem);
  • hormone substitute remedy and hormonal contraception (being pregnant management tablets, patches, rings, implants, and injections);
  • insulin or different medication to deal with excessive blood sugar or diabetes;
  • isoniazid (INH);
  • MAO inhibitors comparable to isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate);
  • bronchial asthma and flu medicines;
  • medication for psychological issues and nausea;
  • miconazole (Monistat);
  • niacin;
  • oral steroids comparable to dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone);
  • phenytoin (Dilantin);
  • probenecid (Benemid);
  • quinolone and fluoroquinolone antibiotics comparable to cinoxacin (Cinobac), ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Nocoxox) , ofloxacin (Floxin), sparfloxacin (Zagam), trovafloxacin and alatrofloxacin mixture (Trovan);
  • rifampin (Rifadin);
  • anti ache salicylate comparable to choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan’s, others), and salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics comparable to co-trimoxazole (Bactrim, Septra);
  • sulfasalazine (Azulfidine);
  • exenatide (Byetta)
  • probenecid (Benemid)

Can meals or alcohol work together with glimepiride?

Sure medicines shouldn’t be used when consuming or when consuming sure meals as a result of drug interactions can happen. Consuming alcohol or tobacco with sure medication may also trigger interactions to happen. Focus on your use of medicine with meals, alcohol, or tobacco together with your well being care supplier.

What well being situations can work together with glimepiride?

Different well being issues in your physique can have an effect on using this drug. Inform your physician if in case you have different well being issues once you wish to use glimepiride, together with:

  • alcohol poisoning
  • adrenal glands are much less energetic
  • pituitary gland is much less energetic
  • malnutrition situation
  • weak bodily situation
  • different situations that trigger low blood sugar ranges. The reason being, sufferers with this situation are extra susceptible or have the next threat of experiencing low blood sugar.
  • diabetic ketoacidosis (keto within the blood)
  • a historical past of Sulfonamide allergy symptoms (antibiotics or abdomen drugs, comparable to sulfamethoxazole, sulfasalazine, sulfisoxazole, Azulfidine®, Bactrim®, or Septra®)
  • kind 1 diabetes. When you have this situation, glimepiride shouldn’t be utilized by sufferers.
  • fever
  • an infection
  • operation
  • Trauma. This situation may cause momentary issues with blood sugar management and your physician could deal with you with momentary insulin
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency (enzyme drawback) deficiency. Could cause hemolytic anemia (blood issues) in sufferers with this situation
  • coronary heart illness. Use this medication with warning. Can worsen this situation
  • Kidney sickness
  • liver illness. Use this medication with warning. Results can improve because of slowing down the disposal of medicine from the physique.

Overdose

What ought to I do in an emergency or overdose?

In circumstances of emergency or overdose, contact the native emergency companies supplier (112) or instantly to the closest hospital emergency division.

Signs of overdose from using glimepiride embody signs of hypoglycemia comparable to:

  • convulsions
  • lack of consciousness

What ought to I do if I miss a dose?

For those who overlook one dose of this medication, take the dose as quickly as doable. But when it seems once you wish to take a missed dose, the time has proven to take the following dose, skip the forgotten dose and return to the same old dosage schedule.

Don't double the dose as a result of a double dose received't assure whether or not you may really feel the advantages of glimepiride sooner than not doubling it. As well as, you have no idea whether or not doubling the dose is not going to improve the chance of negative effects from utilizing the drug or not.

At all times seek the advice of your physician concerning the dosage of drug use, as a result of the physician who checks your situation actually is aware of extra about using doses which are extra applicable and in accordance together with your well being situations.

Good day Well being Group doesn’t present medical recommendation, analysis or therapy.

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