Categories: Medicine A-Z

Lopinavir + Ritonavir – A-Z Medicine


What is lopinavir + ritonavir for?

This product combination contains two drugs: lopinavir and ritonavir. This product is used with other HIV drugs to help control HIV. This drug helps reduce HIV levels in the body so that the immune system can work better. This will reduce the chance of getting HIV complications (such as new infections, cancer) and improve your quality of life. Lopinavir and ritonavir belong to a class of drugs known as HIV protease inhibitors. Ritonavir increases lopinavir levels thereby helping to work better lopinavir.

Lopinavir / ritonavir is not a cure for HIV infection. To reduce the risk of spreading HIV to others, do all of the following: (1) continue to use all HIV drugs exactly as prescribed by the doctor, (2) always use effective contraceptive methods (latex or polyurethane condoms / dental dams) for all sexual activity, and (3) do not share personal items (such as needles / syringes, toothbrushes and razors) that may have been exposed to blood or other bodily fluids. Consult a doctor or pharmacist for more details.

OTHER USES: This section contains the use of this drug which is not listed on an approved label, but may be prescribed by your health care professional. Use this medicine for the conditions listed below only if it has been prescribed by your doctor and health professional. This product can also be used in conjunction with other HIV drugs to reduce the risk of contracting HIV infection after contact with the virus. Consult your doctor for more details.

How to use lopinavir + ritonavir?

Take this medicine with or without food according to doctor's directions, usually once or twice a day. Swallow tablets directly. Do not crush or chew the tablet. The dosage is based on your medical condition, response to medication and other medications you are taking. Be sure to tell your doctor and pharmacist all the products you are using (including prescription, non-prescription drugs and herbal products). For children, dosage based on age, weight and height. A once-daily dose is not recommended for children under 18 years. If you consume didanoside for this product, you can drink it at the same time as this product but don't take it without eating.

It is important to continue taking this drug (and other HIV drugs) exactly as prescribed by the doctor. Do not miss any dose. This medicine works best when the amount of medication in your body is kept at a constant level. Therefore, take this medicine at balanced intervals. To help you remember, drink at the same time every day. Do not consume more or less than recommended or stop taking it (or other HIV drugs) even for a short time unless directed by a doctor. This can cause the amount of virus to increase, making infection more difficult to treat or worse side effects.

How is lopinavir + ritonavir stored?

You can store the medicine in the refrigerator until the expiration date printed on the label, or you can store it at room temperature for up to 2 months. Do not store in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product packaging or ask your pharmacist. Keep all medicines out of the reach of children and pets.

Do not flush medicine in the toilet or in the sewer unless instructed. Discard this product when it has expired or if it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.


The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

Follow the doctor's advice or the dosage instructions provided on the medicine packaging.

Side effects

What side effects can be experienced due to lopinavir + ritonavir?

Seek immediate medical attention if you experience any of the following signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Stop using this medicine and contact your doctor if you experience any of the following serious side effects:

Kepala headache accompanied by chest pain and dizziness, fainting, rapid heart palpitations or palpitations
⇒ vision changes
⇒ increased urination or extreme thirst
Penis painful erection of the penis or lasting more than 4 hours
⇒ signs of a new infection, such as fever or chills, cough, or flu symptoms
⇒ sweating, hand tremors, anxiety, irritability, sleep problems (insomnia)
⇒ diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex
⇒ swelling in the neck or throat (enlarged thyroid)
⇒ muscle weakness, fatigue, joints or muscle aches, shortness of breath
⇒ problems when walking, breathing, talking, swallowing, or moving the eyes
⇒ prickly feeling in fingers or toes, severe lower back pain, loss of bladder
Parah severe pain in the upper abdomen spreading to the back, nausea and vomiting
⇒ loss of appetite, itching, dark urine, dark stools, jaundice (yellowing of the skin or eyes)

Parah severe skin reactions – fever, sore throat, swelling in the face or tongue, burning in your eyes, skin ache, followed by a red or purple skin rash that spreads (especially on the face or upper body) and blisters or peeling.

Not so serious side effects include:
⇒ mild nausea, vomiting, abdominal pain
⇒ mild skin rash
⇒ headache
⇒ changes in the shape or location of body fat (especially in your arms, legs, face, neck, chest, and waist).
Not everyone experiences these side effects. There may be some side effects not listed above. If you have concerns about side effects, please consult a doctor or pharmacist.

Prevention & Warnings

What must be known before taking lopinavir + ritonavir?

Before using this drug, tell your doctor if you are allergic to lopinavir, ritonavir (ritonavir), another drug, or one of the ingredients in lopinavir and ritonavir tablets. Ask the pharmacist for a list of ingredients. Tell your doctor if you are taking any of the following drugs: alfuzosin (Uroxatral) cisapride (Propulsid) (not available S). Ergot medications such as dihydroergotamine (DHE 45, Migranal), ergonovine, ergotamine (Ergomar, in Cafergot, in Migergotamine) ), and methylergonovine (Methergine) lovastatin (Altoprev, Mevacor, in Advicor) midazolam (Versed) pimozide (Orap) rifampin (Rimactane, Rifadin, in Rifamate, in Rifater) sildenafil simvastatin (Simcor, Zocorion or Vocolion) ). Your doctor may tell you to stop taking lopinavir and ritonavir if you take one of these drugs.

Tell your doctor if you are taking prescription or non-prescription drugs, herbal supplements, or vitamins. Don't forget to mention: anticoagulants ('blood thinners') such as warfarin (Coumadin) antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend) atovaquone (Mepron, in Malarone) beta-blockers bocepreviran (Victrelis) boss Tracleer) bupropion (Wellbutrin, Zyban) calcium-channel blockers such as felodipine, nicardipine (Cardene), and nifedipine (Adalat, Procardia) cholesterol drugs such as atorvastatin (Lipitor), and rosuvastatin (Crestor) clarithromycin (Biaxin) colchicine) (Lanoxin) fentanyl (Actiq, Duragesic, Onsolis) fluticasone (Advair, in Flovent) fosamprenavir (Lexiva) cancer drugs such as dasatinib (Sprycel), nilotinib (Tasigna). vinblastine, and vincristine cardiac drugs such as amiodarone (Cordarone, Pacerone), lidocaine, and quinidine (Quinidex) seizure-suppressing drugs such as carbamazepine (Equetro, Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin) immunosuppressive drugs (cyclosporine such as cyclosporine (cyclos) Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf) methadone (Dolophine) oral steroids such as dexamethasone (Decadron, Dexone) antiviral drugs such as abacavir (Ziagen, in Epzicom, in Trizivir) orzanavir (Reyataz), delaviorine (delaviorine) (delaviorine)) , efavirenz (Sustiva), indinavir (Crixivan), maraviroc (Selzentry), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), tenofovir (Viread, in Atripla, in Truvada), tipranavir (Aptivus), saquinavir (saquinavir) ), and zidovudine (Retrovir, Combivir, Trizivir) rifabutin (Mycobutin) salmeterol (Serevent, Advair) sildenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) sulfenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) sulfenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) sulfenafil (Viagra) tadalafil (Adcirca, Cialis) trazodone (Oleptro) and vardenafil (Levitra) disulfiram methylid (Antaboleid) . Your doctor can monitor your dosage. If you take didanoside drink 1 hour before or 2 hours after taking lopinavir and ritonavir with food. If you take lopinavir and ritonavir tablets, you can take them on an empty stomach together with didanoside. Tell the doctor which herbal products you are using, especially products that contain St. John's wort. You should not take St. John's wort during treatment with lopinavir and ritonavir.

Tell your doctor if you have or have had a long QT interval (a rare heart problem that can cause irregular heartbeats, fainting, or sudden death), irregular heartbeat, low blood potassium levels, hemophilia, high cholesterol or triglycerides (fat ) in the blood, pancreatitis (pancreatic swelling), or heart or liver disease. lopinavir and ritonavir reduce the effectiveness of hormonal contraception (birth control pills, patches, rings, or injections). Talk to your doctor about how to use other forms of contraception that you can use. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. If you become pregnant while taking lopinavir and ritonavir, call your doctor. Do not breastfeed if you are infected with HIV or if you take lopinavir and ritonavir.

You should know that certain ingredients in lopinavir and ritonavir solutions can cause serious and life-threatening side effects in newborns. Lopinavir and ritonavir oral solutions should not be given to full-term babies younger than 14 days or premature babies younger than the last 14 days of their original due date, unless doctors think there is a good reason for babies to receive the right medication after birth. If your baby's doctor chooses to give your baby lopinavir and a ritonavir solution immediately after birth, your baby will be carefully monitored for signs of serious side effects. Contact your baby's doctor immediately if your baby is very sleepy or has a change in breathing during his treatment with lopinavir and an oral ritonavir solution.

Body fat can increase or move to other areas of the body such as the upper back, neck, breasts, and around the abdomen. You may see loss of body fat from the face, legs and arms. You can experience hyperglycemia (an increase in your blood sugar levels), even if you don't already have diabetes. Tell your doctor right away if you have the following symptoms when you take lopinavir and ritonavir: extreme thirst, frequent urination, extreme hunger, blurred vision. It is important to contact a doctor immediately after having these symptoms, because untreated high blood sugar can cause a serious condition called ketoacidosis. Ketoacidosis can be life-threatening if not treated at an early stage. Symptoms of ketoacidosis include: dry mouth, nausea and vomiting, shortness of breath, fruity breath, and decreased awareness. When taking medicine to treat HIV infection, your immune system may get stronger and start fighting other infections that are already in your body. This can cause symptoms to develop from infection. If you have new symptoms or worsen after starting treatment with lopinavir and ritonavir, be sure to tell your doctor.

Is lopinavir + ritonavir safe for pregnant and lactating women?

There is no adequate research on the risks of using this drug in pregnant or nursing women. Always consult a doctor to consider the potential benefits and risks before using this medicine.

This drug is included in the risk of pregnancy category C according to the US Food and Drugs Administration (FDA). The following are references to pregnancy risk categories according to the FDA:

  • A = No risk,
  • B = No risk in several studies,
  • C = Maybe risky,
  • D = There is positive evidence of risk,
  • X = Contraindications,
  • N = Unknown

Nursing mothers should not take this medicine. Even though the baby is not infected with HIV, it can be transmitted through breast milk


What medicines might interact with lopinavir + ritonavir?

Drug interactions can change the performance of your medication or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / nonprescription medicines and herbal products) and consult your doctor or pharmacist. Do not start, stop or change the dose of any drug without the doctor's approval.

  • atovaquone
  • bosentan
  • colchicine
  • disulfiram (Antabuse)
  • lamotrigine
  • salmeterol with or without fluticasone
  • an antibiotic – clarithromycin, metronidazole, rifabutin
  • an antidepressant – bupropion, trazodone
  • Antifungal drugs such as itraconazole, ketoconazole, voriconazole
  • blood thinners such as rivaroxaban, warfarin, Coumadin
  • cancer drug
  • cholesterol drugs such as atorvastatin, rosuvastatin
  • medications for pulmonary arterial hypertension avanafil, sildenafil (Viagra), tadalafil, vardenafil
  • heart or blood pressure medications such as amiodarone, felodipine, lidocaine, nicardipine, nifedipine, quinidine
  • hepatitis C drug boceprevir or telaprevir
  • medicine to avoid organ rejection of transplants
  • narcotic drugs – fentanyl, methadone
  • other HIV AIDS drugs such as efavirenz, nevirapine, nelfinavir
  • seizure medication – carbamazepine, phenobarbital, phenytoin, valproic acid or
  • steroid drugs such as budesonide, dexamethasone, fluticasone, prednisone.

Can food or alcohol interact with lopinavir + ritonavir?

Certain medicines should not be used when eating or at around meal times for certain foods or foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with lopinavir + ritonavir?

The presence of other medical problems can affect the use of this drug. Make sure you tell your doctor if you have other medical problems.


  • cirrhosis
  • diabetes mellitus
  • hemophilia bleeding problem)
  • hyperglycemia (high blood pressure)
  • hyperlipidemia (high blood pressure, high fat)
  • liver problems (hepatitis B or C)
  • pancreatitis
  • shortness of heart
  • heart failure (cardiomyopathy, ischemic heart disease)
  • other heart problems
  • hypokalemia (low potassium) – be careful because it can increase the risk.


What should I do in an emergency or overdose?

In cases of emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget one dose of this medicine, take it as soon as possible. But when it is nearing the next dose, skip the missed dose and return to the usual dosage schedule. Do not double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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