Categories: Medicine A-Z

Paclitaxel what medicine? – A-Z Medicine


Generic Name:
Paclitaxel


Brand:
Ebetaxel, Paclimedac, Paxus, Santotaxel, Sindaxel, Anzatax and Taxol.

Use

What is Paclitaxel for?

Paclitaxel is a drug used to treat various types of cancer. This drug is a cancer chemotherapy drug that works by slowing or stopping the growth of cancer cells.

How to use Paclitaxel?

Read the information in the leaflets available from your pharmacist before you start using paclitaxel. If you have questions, consult your doctor or pharmacist.

This drug is given by injection into a vein by a professional health nurse. This medicine is given according to a schedule directed by your doctor. The dosage is based on your medical condition, body size, and response to treatment.

How to store Paclitaxel?

This drug is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product packaging or ask your pharmacist. Keep all medicines out of the reach of children and pets.

Do not flush medicine in the toilet or in the sewer unless instructed. Discard this product when it has expired or if it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.

Dose

The information provided is not a substitute for medical advice. Always consult your doctor or pharmacist before starting treatment.

What is the dose of paclitaxel for adults?

Normal Doses for Adults with Ovarian Cancer

For ovarian cancer patients who have never been treated before:

175 mg / m2 infused more than 3 hours every 3 weeks followed by cisplatin or

135 mg / m2 infused for 24 hours every 3 weeks followed by cisplatin

For patients previously treated for ovarian cancer:

175 mg / m2 infused more than 3 hours every 3 weeks or

135 mg / m2 infused more than 3 hours every 3 weeks

Normal Dosage for Adults with Kaposi's Sarcoma

For patients with diseases related to Kaposi's AIDS Sarcoma:

135 mg / m2 infused more than 3 hours every 3 weeks or

100 mg / m2 infused more than 3 hours every 2 weeks

Note: In patients with advanced HIV disease:

1) Reduce the dose of dexamethasone as one of the three premedication drugs to 10 mg (not 20 mg orally)

2) Starting or repeating treatment with paclitaxel only if the neutrophil count is at least 1,000 cells / mm3

3) Reducing the next dose of paclitaxel consumption by 20% for patients with severe neutropenia (a neutrophi count <500 cells / mm3 for a week or more)

4) Consumption together with hematopoietic growth factor (G-CSF) as a clinical indication.

Normal Doses for Adults with Breast Cancer – Adjuvant

For treatment of relief from node-positive:

175 mg / m2 infused over 3 hours every 3 weeks for four programs given sequentially for chemotherapy containing doxorubicin.

Normal Doses for Adults with Breast Cancer

After failure of initial chemotherapy for metastatic disease or recurrence within 6 months of chemotherapy help:

175 mg / m2 infused more than 3 hours every 3 weeks

Normal Doses for Adults Patients with Lung Cancer Cells that are Not Small

135 mg / m2 infused for 24 hours followed by cisplatin every 3 weeks

What is the dose of paclitaxel for children?

Safety and effectiveness in pediatric patients (less than 18 years) have not been established.

At what dose is Paclitaxel available?

Concentration, infusion: 100mg / 16.7 mL (16.7 mL); 30 mg / 5 mL (5 mL); 150 mg / 25 mL; 300 mg / 50 mL (50 mL).

Side effects

What side effects can be experienced because of Paclitaxel?

Nausea, vomiting, diarrhea, thrush, muscle / joint pain, numbness / tingling / sensation of burning hands / feet, rinsing, dizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor immediately.

Temporary hair loss can occur. Normal hair growth usually returns after treatment has ended.

This drug is possible but rarely causes changes in blood pressure and heart rate. You must be monitored to see changes during this drug infusion. Immediately tell your doctor if you feel increasingly dizzy, headache, or fast / slow / irregular heartbeat.

Many people who use this drug get serious side effects. However, your doctor has prescribed this medication because he has rated that the benefits for you outweigh the risks of side effects. Careful monitoring by your doctor can reduce your risk.

Tell your doctor immediately if you have serious side effects, including: signs of anemia (for example, unusual fatigue, pale skin), easy bruising / bleeding, fainting, confusion, pain / redness / swelling / weakness in the arm / feet, calf pain / swelling that is warm to the touch, coughing up blood, continuous nausea / vomiting, stomach / abdominal pain, yellowing eyes / skin, dark urine, vision / hearing changes, convulsions.

These drugs usually do not irritate veins, are given in leakage or blood comes out of the veins and irritate the area. This effect can cause redness, pain, swelling, discoloration, or unusual skin reactions at the injection site, either when the drug is given or about 7 to 10 days later. If this drug has leaked from a vein and caused a skin reaction in the past, you may rarely experience skin reactions in the same area when the drug is given again, even when the drug is given to another area. Immediately tell your doctor all symptoms that occur in the skin / injection area.

Prevention & Warnings

What should you know before using Paclitaxel?

Before using paclitaxel, tell your doctor or pharmacist if you have an allergy to this drug; or if you have other allergies. This product may contain active ingredients (such as polyoxyethylated castor oil), which can cause allergic reactions or other problems. Discuss with your pharmacist for more details.

Before using this medicine, tell your doctor or pharmacist your medical history, especially: blood disorders (for example, low white blood cell counts), decreased bone marrow function, infections, heart problems (for example, fast / slow / irregular heartbeat), high or low blood pressure, liver disease.

This medicine may make you dizzy or drowsy. Don't drive, use machinery, or do activities that require vigilance until you are sure you can do activities safely. Limit alcoholic drinks.

Is Paclitaxel safe for pregnant and breastfeeding women?

There is no adequate research on the risks of using this drug in pregnant or nursing women. Always consult your doctor to consider the potential benefits and risks before using this medicine. This drug is included in the risk of pregnancy category D according to the US Food and Drugs Administration (FDA).

The following are references to pregnancy risk categories according to the FDA:

  • A = No risk,
  • B = No risk in some studies,
  • C = Maybe risky,
  • D = There is positive evidence of risk,
  • X = Contraindications,
  • N = Unknown

There is no data on whether paclitaxel can be distributed through breast milk. Because many drugs can be channeled through breast milk, and because of the potential for serious side effects in nursing babies, mothers should stop breastfeeding while undergoing treatment with Paclitaxel.

Animal studies have shown that giving paclitaxel carbon-14 infusion on days 9 to 10 after giving birth, found radioactivity concentrations higher in breast milk than in plasma and decreased in parallel with plasma concentrations.

Interaction

What medicines might interact with paclitaxel?

Using this drug with one of the following medicines is usually not recommended, but may be needed in some cases. If the two drugs are prescribed together, your doctor can change the dosage or how often you use one or both drugs.

  • Abiraterone Acetate
  • Adenovirus Vaccine Type 4, Life
  • Adenovirus Vaccine Type 7, Life
  • Aprepitant
  • Bacillus Calmette from and Guerin Vaccine, Life
  • Bexarotene
  • Carbamazepine
  • Ceritinib
  • Cisplatin
  • Cobicistat
  • Crizotinib
  • Dabrafenib
  • Deferasirox
  • Doxorubicin
  • Liposome Doxorubicin Hydrochloride
  • Eslicarbazepine Acetate
  • Etinil Estradiol
  • Fluconazole
  • Fosaprepitant
  • Idelalisib
  • Infliximab
  • Influenza Virus Vaccine, Life
  • Ketoconazole
  • Measles Virus Vaccine, Life
  • Mitotane
  • Vaccine Virus Mumps, Alive
  • Nilotinib
  • Pazopanib
  • Piperaquine
  • Pixantrone
  • Primidone
  • Rubella Virus Vaccine, Alive
  • Siltuximab
  • Smallpox Vaccine
  • St. John's wort
  • Testosterone
  • Tretinoin
  • Typhus Vaccine
  • Valspodar
  • Varicella Virus Vaccine
  • Yellow Fever Vaccine

Using this drug with one of the following medicines can cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If the two drugs are prescribed together, your doctor can change the dosage or how often you use one or both drugs.

  • Dalfopristin
  • Epirubicin
  • Fosphenytoin
  • Lapatinib
  • Phenytoin
  • Quinupristin

Can food or alcohol interact with paclitaxel?

Certain medicines should not be used when eating or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with paclitaxel?

The presence of other medical problems can affect the use of this drug. Make sure you tell your doctor if you have other medical problems, especially:

  • bradycardia (slow heart rate)
  • heart rhythm problems
  • hypertension (high blood pressure)
  • hypotension (low blood pressure)
  • peripheral neuropathy (pain, numbness, or tingling of hands, arms, legs, or feet) – use caution. Might make conditions worse
  • infection – can decrease your body's ability to fight infection
  • liver disease – use with caution. Side effects can increase due to slower removal of drugs from the body
  • neutropenia, severe (very low white blood cells) – do not use it in patients with this condition.

Overdose

What should I do in an emergency or overdose?

In cases of emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

Symptoms of an overdose may include:

  • pale skin
  • hard to breathe
  • excessive fatigue
  • sore throat, fever, chills, and other signs of infection
  • unusual bruising or bleeding
  • numbness, burning, or tingling in the hands and feet
  • mouth sores

What should I do if I miss a dose?

If you forget one dose of this medicine, take it as soon as possible. But when it is nearing the next dose, skip the missed dose and return to the usual dosage schedule. Do not double the dose. Contact your doctor immediately if you cannot fulfill your appointment to receive a dose of paclitaxel infusion.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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