Categories: Medicine A-Z

What drug Captopril? – A-Z Medicine

Generic Name:

Acendril, Farmoten, Otoryl, Tensicap, Tensobon, Vapril, Acepress, Captensin, Hextoparm Captopril, Indo Farma Captopril, Captopril Landson, Dexacap, Inapril, Lotensin, Metopril, Scantensin, Tenofax and Captopril-drugs-high-blood-hypertension-dose-Captopril function.


What is Captopril for?

Captopril is a medicine for treating high blood pressure (hypertension). Captropril belongs to a group of heart medicines called ACE inhibitors.

This drug works by inhibiting the angiotensin-converting enzyme which then decreases the amount of angiotensin II (a hormone that causes blood vessel constriction and increases blood pressure)

In addition to treating hypertension, captopril also helps prevent it stroke, heart attack, diabetic nephropathyand kidney problems. How to use, dostoptopril and side effects of captopril will be explained further below.

How to use

What are the rules for taking Captopril?

Some rules that you must understand when taking captopril are:

  • Take captopril on an empty stomach (at least 1 hour before meals) as recommended by your doctor, usually two or three times a day. Dose is determined based on your health condition and response to treatment.
  • Use this medication regularly for the best results. To help you remember to drink at the same time every day. It is very important to continue using this medicine even if you feel better.
  • For the treatment of heart failure, it may take several weeks to several months before you can feel the benefits of this drug.

Call a doctor if your condition does not improve or if it gets worse.

How to store Captopril?

This drug is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom. Don't freeze it.

Other brands of this drug may have different storage rules. Observe the storage instructions on the product packaging or ask your pharmacist. Keep all medicines out of the reach of children and pets.

Do not flush medicine in the toilet or in the sewer unless instructed. Discard this product when it has expired or if it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.


The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of Captopril for adults?

For high blood pressure or hypertension, the dosage of the use of captopril is as follows:

Hypertension is another name for high blood pressure. Blood pressure itself is the power of blood flow from the heart that pushes against the walls of blood vessels (arteries).

The strength of this blood pressure can change from time to time, influenced by what activity the heart is doing (such as exercising or in a state of rest) and the resistance of its arteries.

High blood pressure is a condition where blood pressure higher than 140/90 millimeter of mercury (mmHG). The figure of 140 mmHG refers to systolic readings, when the heart pumps blood throughout the body.

Meanwhile, the number 90 mmHG refers to diastolic readings, when the heart is relaxed while refilling its chambers with blood. The following dose is used:

  • Initial dose: captopril 25 mg orally, 2-3 times a day one hour before meals.
  • Continued dose: captopril 25-150 mg orally, 2-3 times a day one hour before meals.

For heart failure, the dose of captopril is:

Heart failure is a term used to describe the state of the heart that cannot function properly and is unable to pump blood throughout the body efficiently.

In people with heart failure, blood moves throughout the body more slowly through the heart. Due to insufficient amount of blood, the heart chambers respond by stretching to hold more blood or by becoming stiff and thickened.

This condition can help to keep blood moving, but the heart muscle will eventually weaken and not be able to work effectively.

As a result, it triggers the kidneys to hold more fluid and salt. Finally, fluid builds up in parts of the body and causes blockages. Heart failure is a different condition from heart attack and weak heart.

  • Initial dose: 25 mg oral captopril 3 times daily (6.25-12.5 mg orally, 3 times daily if volume is reduced or hypotensive).
  • Follow-up dose: after captopril dose of 50 mg three times daily is reached, additional doses should be postponed at least 2 weeks to see whether a satisfactory response occurs. Many of the patients studied progressed from 50-100 mg three times a day. Captopril generally must be used together with diuretics and digitalis.

For left heart chambers damage, the dose of using captopril is:

When the left portion of the heart does not pump blood out, blood will accumulate in the heart or clog in the organs or tissues, causing blood to accumulate in the circulatory system.

If the left heart fails, the right heart system will be congested due to accumulated blood. Inside, the heart is blocked from excess contractions which encourage blood and can cause heart failure.

However, if the right part of the heart fails, the left heart is affected and can also cause it heart failure. The following dose is used:

  • Initial dose: 6.25 mg orally for 1 dose, then 12.5 orally 3 times a day.
  • Increased dose: the dose is increased to 25 mg orally 3 times a day in the next few days.
  • Continued dose: the dose is increased to the target dose of 50 mg oral captopril 3 times a day for several weeks thereafter according to the patient's tolerance.

Therapy may begin 3 days after myocardial infarction (damage to the heart myocardium). Captropil can also be used in patients on other postmyocardial infarction treatments such as thrombolytics, aspirin, beta blockers.

For diabetic nephropathy, the dosage of captropil is:

Diabetic nephropathy is a type of progressive kidney disease that occurs in people who have diabetes. Experts estimate that 20-40 percent of people with diabetes will experience diabetic nephropathy at some point in their lives.

Diabetic nephropathy takes place slowly. The average time needed to progress from the early stages of end-stage renal failure to kidney disease is 23 years. However, not everyone develops to stage five of the disease. Next use the dose:

  • The recommended dosage for the long term is 25 mg orally three times a day.

For emergency hypertension, the dose of the use of the captopril drug is:

  • When an immediate increase in blood pressure is indicated, continue with diuretic therapy and stop drug therapy, and give captopril 25 mg 2-3 times a day under close observation.
  • Increase the dose every 24 hours or less until a satisfactory response is reached or the maximum dose has been reached.

For kidney stones, the dose of captopril is:

Kidney stones are conditions that occur due to hard deposits that are formed from amino acids present in urine. The process is called nephrolithiasis.

Kidney stones or urinary stones are usually very small or can reach about a few inches. The larger stone size that fills the channel that carries urine from the kidney to the bladder is called staghorn stone. The following dosage is the use of the drug:

  • Initial dose: Captopril 25 mg orally two to 3 times a day one hour before meals. Initial doses may be titrated as tolerance patients around every 1-2 weeks to reduce the level of cystinuria.

What is the dose of Captopril for children?

Safety and effectiveness of captopril have not been established in pediatric patients (under the age of 18).

In what dosage is Captopril available?

Availability of captopril drug dosages are:

  • Tablets, oral: 6.25 mg, 12.5 mg, 25 mg, 50 mg, 100 mg.

Side effects

What side effects can be experienced because of Captopril?

Possible side effects of using captopril are:

  • Cough
  • Loss of sense of taste, loss of appetite
  • Dizziness, drowsiness, headache
  • Sleep disorders (insomnia)

More serious side effects of captopril are listed below. See a doctor immediately if you experience the following side effects:

  • Mild feeling on the head, fainting
  • Urinate more or less, or not at all
  • Fever, chills, pain, flu symptoms
  • Pale skin, difficulty breathing, rapid heartbeat, difficulty concentrating
  • Easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red spots under the skin
  • Rapid or unstable heartbeat
  • Chest pain
  • Swelling, rapid weight gain

Not everyone experiences the above side effects. There may be some side effects not mentioned above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Prevention & Warnings

What should be known before using Captopril?

Do not use this medicine if you have an allergy to Captopril. Before using Captopril, tell your doctor if you have an allergy to any medication, or if you have:

  • Kidney illness
  • Hearing difficulties

If you have these conditions, you may need dosage adjustments or special tests to use Captopril safely.

Is Captopril safe for pregnant and lactating women?

There is no adequate research on the risk of using captopril in pregnant or breastfeeding women. Always consult your doctor to consider the potential benefits and risks before using this medicine. This drug is included in the risk of pregnancy category D (there is evidence of risk) according to the US Food and Drugs Administration (FDA)

The following are references to pregnancy risk categories according to the FDA:

  • A = No risk
  • B = No risk in several studies
  • C = Maybe risky
  • D = There is positive evidence of risk
  • X = Contraindications
  • N = Unknown


What medicines might interact with Captopril?

Although certain drugs are not recommended for use together, in other cases two different drugs can be used together although drug interactions may occur. In cases like this, your doctor may change the dosage, or other precautions that need to be taken. Notify your health care provider if you use other prescription or non-prescription drugs.

The use of this drug with the drugs attached below is not recommended. Your doctor may decide not to continue treatment with this drug or replace the other medication you are using.

The use of this drug with the drugs attached below is generally not recommended, but may be needed in some cases. If the two drugs are prescribed together, your doctor may change the dosage or how often one drug is used.

  • Afatinib
  • Allopurinol
  • Alteplase, Recombinant
  • Amiloride
  • Azathioprine
  • Azilsartan
  • Bosutinib
  • Candesartan Cilexetil
  • Canrenoate
  • Dabigatran Etexilate
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Eplerenone
  • Eprosartan
  • Everolimus
  • Interferon Alfa-2a
  • Irbesartan
  • Losartan
  • Morphine
  • Morphine Sulfate Liposome
  • Nilotinib
  • Olmesartan Medoxomil
  • Pixantrone
  • Pomalidomide
  • Potassium
  • Romidepsin
  • Spironolactone
  • Telmisartan
  • Topotecan
  • Trabectedin
  • Triamterene
  • Trimethoprim
  • Valsartan
  • Vincristine
  • Vincristine Sulfate Liposome

The use of this drug with the drugs attached below can lead to an increased risk of certain side effects, but the use of both drugs may be the best treatment for you. If the two drugs are prescribed together, your doctor may change the dosage or how often one drug is used.

  • Aceclofenac
  • Acemetacin
  • Amtolmetin Guacil
  • Aspirin
  • Azosemide
  • Bemetizide
  • Bendroflumethiazide
  • Benzthiazide
  • Bromfenac
  • Bufexamac
  • Bumetanide
  • Bupivacaine
  • Bupivacaine Liposome
  • Buthiazide
  • Capsaicin
  • Celecoxib
  • Chlorothiazide
  • Chlorpromazine
  • Chlorthalidone
  • Choline Salicylate
  • Clonixin
  • Clopamide
  • Cyclopenthiazide
  • Cyclothiazide
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digoxin
  • Dipyrone
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Phenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Furosemide
  • Gold Sodium Thiomalate
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Ibuprofen Lysine
  • Icatibant
  • Indapamide
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Methyclothiazide
  • Metolazone
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nesiritide
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenylbutazone
  • Piketoprofen
  • Piretanide
  • Piroxicam
  • Polythiazide
  • Pranoprofen
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinethazone
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Trichlormethiazide
  • Valdecoxib
  • Xipamide

Can food or alcohol interact with Captopril?

Certain medicines should not be used when eating or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Captopril?

Other health problems can affect the use of this drug. Tell your doctor if you have other health problems, specifically:

  • Angioedema (swelling of the face, lips, tongue, throat, arms, or legs).
  • Vascular collagen disease (autoimmune disease) together with kidney disease or Scleroderma (autoimmune disease).
  • Systemic lupus erythematosus (SLE).
  • Electrolyte imbalance (example: low sodium in the blood).
  • Fluid imbalance (caused by dehydration, vomiting, or diarrhea).
  • Heart or blood vessel disease (such as aortic stenosis).
  • Liver disease.
  • Kidney problems (including patients undergoing dialysis). The effect can be increased because of the expenditure of drugs from the body more slowly.


What should I do in an emergency or overdose?

In cases of emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget one dose of this medicine, take it as soon as possible. But when it is nearing the next dose, skip the missed dose and return to the usual dosage schedule. Do not double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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