Carglumic Acid or carglumic acid is a form of a man-made enzyme that occurs naturally in the liver. This enzyme is needed to process the excess nitrogen produced when the body metabolizes protein. Without this enzyme, nitrogen builds up in the form of ammonia and is not released from the body. Ammonia is very toxic when it circulates in the blood and tissues and can cause permanent brain damage, coma, or death.
Carcglumic acid is an enzyme used to treat hyperammonemia. This condition occurs due to urea cycle disorders caused by a lack of certain liver enzymes. Carglumic Acid is usually given with other drugs to treat this lifelong disorder.
Carglumic Acid can also be used for purposes not listed in the treatment guidelines.
Carglumic acid is a drug that can be taken according to doctor's requirements. Do not use in larger or smaller amounts or for longer than recommended. Follow the instructions on the label of your recipe.
Your doctor may occasionally change your dose to make sure you get optimal results. Dosing adjustments is very important for your child's growth.
Carglumic acid is a drug that is usually taken 2 to 4 times every day, right before eating. Follow the doctor's instructions for more complete drinking rules.
Also note not to chew, crush, or swallow whole carglumic acid tablets. Generally carglumic acid is used by placing it in a glass of water until the tablet dissolves in water.
Carglumic acid tablets usually will not dissolve completely. Therefore, it is recommended to drink this solution immediately. To make sure you get the entire dose, add less liquid to the same glass, stir a little and drink immediately if there are still remaining tablets left in the glass.
Carglumic acid can be used with a syringe as follows: Place 200 milligrams of a tablet on the syringe and take 2.5 milliliters of water onto the syringe. Shake until the tablet is spread and then pour the syringe into your mouth. Refill the syringe with water, shake gently, and pour it into your mouth.
Carglumic acid tablets can also be given via (NG) nasogastric filling tubes as follows: Dissolve the tablets in the syringe as directed above. Place the syringe into the NG tube and push the plunger down to pour the syringe into the tube. Then flush the tube with more water to wash the contents at the bottom.
To make sure this medicine helps your condition and does not cause harmful effects, your blood needs to be tested more often. An ammonia buildup in the blood can quickly cause brain injury or death. Don't miss any follow-up visits to your doctor for blood tests. Everyone with urea cycle disorders must remain under the care of a doctor.
This drug is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product packaging or ask your pharmacist. Keep all medicines out of the reach of children and pets.
Do not flush medicine in the toilet or in the sewer unless instructed. Discard this product when it has expired or if it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.
The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.
Normal Doses for Adults with Hyperammonemia:
Daily dose the total should be divided into 2 to 4 doses and rounded up to the nearest 100 mg dose.
The initial dose can be consumed 100 to 250 mg / kg taken directly per day divided into 2 to 4 doses of drinking immediately before meals. Other concomitant use of ammonia reduction therapy is also recommended. Doses should be taken based on the patient's individual plasma ammonia levels and clinical symptoms.
Maintenance dose usually used less than 100 mg / kg by taking it directly per day divided into 2 to 4 doses immediately before meals. The recommended maintenance dose should be taken to target the normal level of plasma ammonia for a certain age.
Normal Doses for Children with Hyperammonemia:
Initial dose: 100 to 250 mg and taken immediately per day, in 2 to 4 doses immediately before eating or nursing children.
Concomitant use of other ammonia reduction therapies is recommended. The dosage should be taken based on the patient's individual plasma ammonia levels and clinical symptoms.
For maintenance dose: Usually less than 100 mg / kg taken immediately per day in 2 to 4 doses immediately before eating or breastfeeding.
Carglumic acid preparations can be available in tablet form.
Get emergency medical help if you have any signs of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat.
Contact your doctor right away if you have serious side effects such as:
Less serious side effects may include:
Not everyone experiences these side effects. There may be some side effects not listed above. If you have concerns about side effects, please consult a doctor or pharmacist.
Tell your doctor about all your medical conditions before using carglumic acid. Because this drug is only part of a complete treatment program that may also include special diets and other drugs. It's important to follow a diet plan that was created for you with your doctor or nutrition counselor. You must follow a list of foods that you should eat or avoid certain foods to help control your condition.
There is no adequate research on the risks of using this drug in pregnant or nursing women. Always consult your doctor to consider the potential benefits and risks before using this medicine. This drug is included in the risk of pregnancy category B (according to the US Food and Drugs Administration (FDA)
The following are references to pregnancy risk categories according to the FDA:
Although some drugs may not be taken together at all, in other cases some drugs can also be used together although interactions may occur. In cases like this, the doctor may change the dose, or do other prevention things that are needed. Let your doctor know if you are taking other medicines both over the counter and from a prescription.
Other health conditions that you have can affect the use of this drug. Always tell your doctor if you have other health problems.
In an emergency or overdose, call your local emergency service (112) or go to your nearest emergency room. Symptoms of an overdose may include:
What should I do if I miss a dose?
If you forget one dose of this medicine, take it as soon as possible. But when it is nearing the next dose, skip the missed dose and return to the usual dosage schedule. Do not double the dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
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