Categories: Medicine A-Z

What medicine is phenylbutazone? – A-Z Medicine

Generic Name:

Akrofen, Berlison, Irgapan, Phenylbutazone Molex Ayus and Zonifar.


What is Phenylbutazone for?

Phenylbutazone is a drug that can help to reduce pain and inflammation caused by ankylosing spondylitis when other drugs may not be suitable.

Ankylosing spondylitis is inflammation that causes joint disease that affects the backbone.

How to use Phenylbutazone?

Always use Phenylbutazone tablets exactly as directed by your doctor and always read the label. Your doctor will determine the right dosage according to your condition. Ask your doctor or pharmacist if you are not sure.

  • Take tablets with food or immediately after eating.
  • Swallow tablets entirely with lots of water. Your doctor may ask you to take an antacid (indigestion drug) at the same time.
  • Drinking alcohol while taking Phenylbutazone can cause alcohol effects more than usual.

Follow the rules given by your doctor or pharmacist before starting treatment. If you have questions, consult your doctor or pharmacist.

How is Phenylbutazone stored?

This drug is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product packaging or ask your pharmacist. Keep all medicines out of the reach of children and pets.

Do not flush medicine in the toilet or in the sewer unless instructed. Discard this product when it has expired or if it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.


The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of Phenylbutazone for adults?

The usual starting dose for the first 48 hours is 400 mg to 600 mg daily in divided doses.

The doctor will then reduce the dose to the minimum required amount, usually 200 mg to 300 mg a day in divided doses.

Older patients have a higher risk of side effects and should use the lowest effective dose for the shortest time possible, with additional monitoring done by your doctor.

What is the dose of Phenylbutazone for children?

This drug is not suitable for children under 14 years.

At what dose is Phenylbutazone available?

Tablet: 100 mg; 200 mg

Side effects

What side effects can be experienced due to Phenylbutazone?

Contact your doctor if you have any of the following serious side effects:

  • buzzing in the ears (tinnitus)
  • headache (vertigo)
  • depression
  • hallucination
  • mental confusion
  • dizzy, sleepy, feeling lethargic and tired
  • feeling of numbness, tingling, or heat in the hands or feet
  • asthma or worse than usual asthma (shortness of breath)
  • swelling of the hands, feet (around the ankles) or stomach
  • mouth pain (pain or ulcers on the tongue, cheeks, lips, throat or gums)
  • salivary gland swelling (in front of the ear, under the lower jaw and under the tongue) which can make chewing or swallowing painful, dry mouth
  • the presence of a lump in front of the neck, feeling tired and sensitive to cold, weight gain
  • constipation. This may be due to changes in the reaction of the thyroid gland
  • reaction to the sun. Your skin may become red, painful, and swollen. Do not sunbathe, use tanning bed, or expose your skin to artificial UV light
  • deafness
  • constipation or bloating
  • difficulty swallowing
  • blurred vision, bleeding in the eye
  • feeling sick (malaise)

Not everyone experiences the following side effects. There may be some side effects not mentioned above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Prevention & Warnings

What must be known before using Phenylbutazone?

Do not use phenylbutazone if you:

  • allergic to phenylbutazone or other anti-inflammatory drugs (such as aspirin, buprofen, cielecoxib), or one of the other ingredients (see Section 6)
  • have, or have had, a stomach or intestinal condition such as an ulcer, bleeding in the stomach, large intestine or small intestine, or severe gastritis, especially if you have taken NSAIDs
  • have inflammatory bowel disease (for example ulcerative colitis, Crohn's disease), because phenylbutazone can make this condition worse
  • have severe heart, liver or kidney problems
  • lung problems, swelling or high blood pressure that can affect the heart
  • have thyroid gland disease
  • have or have had a bleeding disorder, or other disorders that affect the blood or cells in your blood
  • have Sjogren's syndrome, which is a disorder in which the mouth and eyes become very dry
  • asthma. Please note that NSAIDs cause asthma attacks, rashes, swelling or inflammation of the nasal cavity
  • use other non-steroidal anti-inflammatory drugs (NSAIDs), (eg ibuprofen, diclofenac)
  • more than 6 months pregnant

If one of the factors above is experienced by you, talk to your doctor or pharmacist.

Is Phenylbutazone safe for pregnant and breastfeeding women?

There is no adequate research on the risks of using this drug in pregnant or nursing women. Avoid use unless you have been diagnosed with a pancreatic problem that requires you to take medication with Phenylbutazone.


What medicines might interact with Phenylbutazone?

Drug interactions can change the performance of your medication or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / nonprescription medicines and herbal products) and consult your doctor or pharmacist. Do not start, stop or change the dose of any drug without the doctor's approval

Please tell your doctor or pharmacist if you are using or have recently used other drugs, including medicines that are obtained without a prescription, and herbal medicines.

Some drugs that can be influenced by phenylbutazone or can affect how well phenylbutazone will work. Tell your doctor or pharmacist if you are also taking:

  • drugs that can increase the occurrence of ulcers or bleeding in the stomach or intestine, such as:

– Corticosteroids are used to treat arthritis and inflammation

– Medications such as anti-platelet agents, which are used to thin the blood (eg warfarin, aspirin, clopidogrel). Your doctor can check your blood for a short time

– Antidepressants called selective serotonin re-uptake (SSRI) inhibitors, (for example


– Other anti-inflammatory drugs (eg diclofenac, celecoxib)

  • medicines used for high blood pressure (for example atenolol, ramipril, valsartan)
  • diuretics (water tablets) or heart medications (eg digoxin, sotalol, diltiazem)
  • some diabetes medications (for example glipizide, glibenclamide) or insulin
  • drugs that suppress the immune system (eg cyclosporine, tacrolimus, methotrexate)
  • lithium, a drug used to treat mood swings and some types of depression
  • a drug that is usually prescribed through a hospital, called mifepristone (taken in the last 12 days)
  • quinolone antibiotics (antibiotics used to treat infections)
  • methylphenidate, a drug used to treat hyperactive conditions
  • anabolic steroids, such as nandrolone
  • misoprostol, a drug used to treat ulcers in the stomach and intestines
  • AZT, a drug used for HIV (human immunodeficiency virus)
  • alcohol
  • The drug used to treat epilepsy is known as phenytoin
  • drugs that affect liver enzymes – (check with your pharmacist). These drugs include barbiturates, chorphenamine, prometazine, rifampicin, cholestyramine, and drugs used to control cholesterol.

Can food or alcohol interact with phenylbutazone?

Certain medicines should not be used when eating or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Phenylbutazone?

Other health problems in your body can affect the use of this drug. Tell your doctor if you have other health problems.


What should I do in an emergency or overdose?

In cases of emergency or overdose, contact the local emergency services provider (112) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget one dose of this medicine, take it as soon as possible. But when it is nearing the next dose, skip the missed dose and return to the usual dosage schedule. Do not double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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