Categories: Medicine A-Z

What medicine is Trihexyphenidyl? – A-Z Medicine

Generic Name:

Arkine, Hexymer, Parkinal, Artane, Trihexyphenidyl Indo Farma and trihexyphenidyl-drug-function-parkinsonism.


What is Trihexyphenidyl used for?

Trihexyphenidyl is a drug for treating symptoms of Parkinson's disease or other movements that cannot be controlled, caused by side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine / haloperidol). This drug helps reduce muscle stiffness, excessive sweating, and saliva production, and helps improve the ability to walk in people with Parkinson's.

Trihexyphenidyl belongs to the class of anticlonergic drugs that work by blocking certain natural substances (acetylcholine). This drug cannot help with the problem of out-of-control movements caused by tardive dyskinesia, and can actually worsen this condition.

The dose of trihexyphenidyl and the side effects of trihexyphenidyl will be explained further below.

What are the rules for taking Trihexyphenidyl?

Follow the rules given by your doctor or pharmacist before starting treatment. If you have questions, consult your doctor or pharmacist.

Trihexyphenidyl is taken usually 3 to 4 times a day after meals and before going to sleep, or according to doctor's directions. Your doctor may give you a low dose to start with and slowly increase the dose to get the right dose for you.

Doses are given based on medical conditions, age, and response to therapy.

If you use the liquid form of this medicine, measure your dose with a measuring spoon or measuring device. Do not use a house spoon because the dosage is incorrect.

Take medication regularly to get maximum results. To help you remember, drink at the same time every day.

Take trihexyphenidyl at least 1 hour before an antacid containing magnesium, aluminum, or calcium. Leave a gap of at least 1-2 hours between a dose of trihexyphenidyl and certain diarrhea drugs (adsorbent antidiarrheals such as kaolin, pectin, attapulgite).

Take this medicine at least 2 hours after ketoconazole. Anatcid and some diarrhea drugs can prevent trihexyphenidyl from being fully absorbed, and this product can prevent ketoconazole from being fully absorbed when these products are taken together.

If you take trihexyphenidyl to treat side effects from other drugs, your doctor may instruct you to take it regularly as scheduled or only when needed. If you take this medication for Parkinson's disease, your doctor may change your other medication dosage (for example, levodopa). Follow the doctor's instructions.

There is a small chance that trihexyphenidyl can be addictive. Do not increase the dose, increase the frequency of taking medication, or take it longer than recommended. Stop using the drug completely when instructed. Some conditions will become worse when treatment is suddenly stopped. Your dosage needs to be decreased slowly

When used for an additional period of time, these drugs may not work well and require different doses. Talk to your doctor if this medication stops working. Let your doctor know if your condition remains the same or worsens.

How is Trihexyphenidyl stored?

This drug is best stored at room temperature, away from direct light and damp places. Do not store in the bathroom. Don't freeze it. Other brands of this drug may have different storage rules. Observe the storage instructions on the product packaging or ask your pharmacist. Keep all medicines out of the reach of children and pets.

Do not flush medicine in the toilet or in the sewer unless instructed. Discard this product when it has expired or if it is no longer needed. Consult your pharmacist or local waste disposal company about how to safely dispose of your product.


The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before starting treatment.

What is the dose of Trihexyphenidyl for adults?

Trihexyphenidyl dose for extrapyramidal symptoms in adults:

Initial dose of 1 mg once a day, can be increased to 5-15 mg per day divided into 3-4 doses.

Trihexyphenidyl dose for Parkinson's disease:

  • Initial dose: 1 mg / day; the dose can be added 2 mg at intervals of 3-5 days
  • Maximum dose: 6-10 mg / day in 3-4 separate doses

What is the dose of Trihexyphenidyl for children?

The dosage for children has not been determined. Consult with your doctor and pharmacist.

In what dosages is Trihexyphenidyl available?

  • Tablets 2 mg; 5 mg
  • Elixir 2 mg / 5 mL

Side effects

What side effects can be experienced due to Trihexyphenidyl?

Trihexyphenidyl side effects that usually occur are:

  • Dry mouth
  • Enlarged eyes or blurred vision
  • Tired or dizzy
  • Difficulty urinating or constipation
  • Nervous or anxious
  • Stomach upset
  • Sweat decreases

If you experience any of the serious side effects below, stop using trihexyphenidyl and seek medical help or contact your doctor immediately:

  • Allergic reactions (difficulty breathing; close the throat; swelling on the lips, tongue, or face; or spots)
  • Fever
  • Fast or irregular heartbeat
  • Anxious, hallucinations, confused, unable to calm down, hyperactivity, or loss of consciousness
  • Convulsions
  • The eye hurts
  • Rash

Not everyone experiences the following side effects. There may be some side effects not mentioned above. If you have concerns about certain side effects, consult your doctor or pharmacist.

Prevention & Warnings

What should be known before using Trihexyphenidyl?

In deciding to use this drug, the risks of using the drug must be considered carefully with the benefits gained later. This is a decision that you and your doctor will make. For this drug, the following you need to consider:


Tell your doctor if you have ever had a different or allergic reaction to this or other medication. And tell your doctor if you have certain allergies, such as food, coloring, preservatives, or animals. For non-prescription products, carefully read the label or ingredients on the packaging.


There is no information available regarding the relationship between age and the effect of trihexyphenidyl in the pediatric population. Safety and success have not yet been proven.


There is no information available regarding the relationship between age and the effect of trihexyphenidyl in elderly patients. However, elderly men tend to have age-related prostrate problems, and all elderly patients tend to have problems between the ages with kidney, liver, or heart conditions. This condition requires attention or trihexyphenidyl dose adjustment for elderly recipient patients.

Is Trihexyphenidyl safe for pregnant and lactating women?

Pregnancy and breastfeeding: there is not enough information regarding safety in the use of trihexyphenidyl during pregnancy and breastfeeding.


What medicines might interact with Trihexyphenidyl?

Drug interactions can change the performance of your medication or increase the risk of serious side effects. Not all possible drug interactions are listed in this document. Keep a list of all the products you use (including prescription / nonprescription medicines and herbal products) and consult your doctor or pharmacist. Do not start, stop or change the dose of any drug without the doctor's approval.

Although some drugs may not be used simultaneously, in other cases two different drugs may be used simultaneously even if interaction is possible. In this case, your doctor may change the dose, or other precautions may be needed. Tell your doctor if you are using another prescription or over-the-counter medicine.

Use this medicine with potassium not recommended. Your doctor may decide not to treat you with this medicine or change some of the drugs you have used.

Using this drug with one of the following medicines is usually not recommended, but may be needed in some cases. If the two drugs come together in a prescription, your doctor may change your dose or frequency using one or both of these drugs.

  • Morphine
  • Morphine Sulfate Liposome
  • Oxymorphone
  • Umeclidinium

Using this drug with one of the following drugs will increase the risk of certain side effects, but using both drugs together may be the best treatment for you. If the two drugs are together in a prescription, your doctor may change the dose or how often you use one or both of these drugs.

  • Betel Nut
  • Chlorpromazine
  • Haloperidol
  • Perphenazine

Can food or alcohol interact with Trihexyphenidyl?

Certain medicines should not be used when eating or when eating certain foods because drug interactions can occur. Consuming alcohol or tobacco with certain drugs can also cause interactions to occur. Discuss your use of drugs with food, alcohol, or tobacco with your health care provider.

What health conditions can interact with Trihexyphenidyl?

Other health problems in your body can affect the use of this drug. Tell your doctor if you have other health problems, specifically:

  • Stomach or intestinal blockage
  • The prostate is enlarged
  • Glaucoma
  • Hypertension (high blood pressure)
  • Urinary obstruction — Use with caution. Can worsen the condition
  • Kidney illness
  • Liver disease — Use with caution. The effect will increase due to the slow delivery of drugs out of the body


What should I do in an emergency or overdose?

In cases of emergency or overdose, contact the emergency services provider (118/119) or immediately to the nearest hospital emergency department.

What should I do if I miss a dose?

If you forget one dose of this medicine, take it as soon as possible. However, when it is nearing the next dose, skip the missed dose and return to the usual dosage schedule. Do not double the dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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